Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors
Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and lead to enhanced barrier function of retinal epit...
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Nature Portfolio
2017
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oai:doaj.org-article:919b83179e8542b08aff5bc2e85e591a2021-12-02T14:42:36ZConcerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors10.1038/ncomms153742041-1723https://doaj.org/article/919b83179e8542b08aff5bc2e85e591a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15374https://doaj.org/toc/2041-1723Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and lead to enhanced barrier function of retinal epithelial cells.Ignacio BenedictoGuillermo L. LehmannMichael GinsbergDaniel J. NolanRohan BarejaOlivier ElementoZelda SalfatiNazia M. AlamGlen T. PruskyPierre LlanosSina Y. RabbanyArvydas MaminishkisSheldon S. MillerShahin RafiiEnrique Rodriguez-BoulanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ignacio Benedicto Guillermo L. Lehmann Michael Ginsberg Daniel J. Nolan Rohan Bareja Olivier Elemento Zelda Salfati Nazia M. Alam Glen T. Prusky Pierre Llanos Sina Y. Rabbany Arvydas Maminishkis Sheldon S. Miller Shahin Rafii Enrique Rodriguez-Boulan Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors |
| description |
Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and lead to enhanced barrier function of retinal epithelial cells. |
| format |
article |
| author |
Ignacio Benedicto Guillermo L. Lehmann Michael Ginsberg Daniel J. Nolan Rohan Bareja Olivier Elemento Zelda Salfati Nazia M. Alam Glen T. Prusky Pierre Llanos Sina Y. Rabbany Arvydas Maminishkis Sheldon S. Miller Shahin Rafii Enrique Rodriguez-Boulan |
| author_facet |
Ignacio Benedicto Guillermo L. Lehmann Michael Ginsberg Daniel J. Nolan Rohan Bareja Olivier Elemento Zelda Salfati Nazia M. Alam Glen T. Prusky Pierre Llanos Sina Y. Rabbany Arvydas Maminishkis Sheldon S. Miller Shahin Rafii Enrique Rodriguez-Boulan |
| author_sort |
Ignacio Benedicto |
| title |
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors |
| title_short |
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors |
| title_full |
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors |
| title_fullStr |
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors |
| title_full_unstemmed |
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors |
| title_sort |
concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/919b83179e8542b08aff5bc2e85e591a |
| work_keys_str_mv |
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1718389643607539712 |