ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

In pancreatic neuroendocrine tumors (PanNETs) ATRX, DAXX, and MEN1 are commonly mutated (A-D-M mutant PanNETs). Here, the authors find in a cohort of PanNETS 58% are A-D-M mutant PanNETs, with a worse clinical outcome and differences in gene expression and methylation compared to A-D-M wild type cas...

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Autores principales:	Chang S. Chan, Saurabh V. Laddha, Peter W. Lewis, Matthew S. Koletsky, Kenneth Robzyk, Edaise Da Silva, Paula J. Torres, Brian R. Untch, Janet Li, Promita Bose, Timothy A. Chan, David S. Klimstra, C. David Allis, Laura H. Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91a16d51722c4f0dab5944814d57ad6b
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spelling	oai:doaj.org-article:91a16d51722c4f0dab5944814d57ad6b2021-12-02T16:56:56ZATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup10.1038/s41467-018-06498-22041-1723https://doaj.org/article/91a16d51722c4f0dab5944814d57ad6b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06498-2https://doaj.org/toc/2041-1723In pancreatic neuroendocrine tumors (PanNETs) ATRX, DAXX, and MEN1 are commonly mutated (A-D-M mutant PanNETs). Here, the authors find in a cohort of PanNETS 58% are A-D-M mutant PanNETs, with a worse clinical outcome and differences in gene expression and methylation compared to A-D-M wild type cases- these gene expression differences suggest that A-D-M mutant PanNETs potentially originate from a cell type similar to alpha cells.Chang S. ChanSaurabh V. LaddhaPeter W. LewisMatthew S. KoletskyKenneth RobzykEdaise Da SilvaPaula J. TorresBrian R. UntchJanet LiPromita BoseTimothy A. ChanDavid S. KlimstraC. David AllisLaura H. TangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chang S. Chan Saurabh V. Laddha Peter W. Lewis Matthew S. Koletsky Kenneth Robzyk Edaise Da Silva Paula J. Torres Brian R. Untch Janet Li Promita Bose Timothy A. Chan David S. Klimstra C. David Allis Laura H. Tang ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
description	In pancreatic neuroendocrine tumors (PanNETs) ATRX, DAXX, and MEN1 are commonly mutated (A-D-M mutant PanNETs). Here, the authors find in a cohort of PanNETS 58% are A-D-M mutant PanNETs, with a worse clinical outcome and differences in gene expression and methylation compared to A-D-M wild type cases- these gene expression differences suggest that A-D-M mutant PanNETs potentially originate from a cell type similar to alpha cells.
format	article
author	Chang S. Chan Saurabh V. Laddha Peter W. Lewis Matthew S. Koletsky Kenneth Robzyk Edaise Da Silva Paula J. Torres Brian R. Untch Janet Li Promita Bose Timothy A. Chan David S. Klimstra C. David Allis Laura H. Tang
author_facet	Chang S. Chan Saurabh V. Laddha Peter W. Lewis Matthew S. Koletsky Kenneth Robzyk Edaise Da Silva Paula J. Torres Brian R. Untch Janet Li Promita Bose Timothy A. Chan David S. Klimstra C. David Allis Laura H. Tang
author_sort	Chang S. Chan
title	ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
title_short	ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
title_full	ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
title_fullStr	ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
title_full_unstemmed	ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
title_sort	atrx, daxx or men1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/91a16d51722c4f0dab5944814d57ad6b
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ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

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