TGF-β1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction

TGF-β1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction

Abstract p16 inhibits cyclin-dependent kinases and regulates senescence-mediated arrest as well as p21. Nuclear p16 promotes G1 cell cycle arrest and cellular senescence. In various glomerular diseases, nuclear p16 expression is associated with disease progression. Therefore, the location of p16 is...

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Autores principales: Sayo Ueda, Tatsuya Tominaga, Arisa Ochi, Akiko Sakurai, Kenji Nishimura, Eriko Shibata, Shu Wakino, Masanori Tamaki, Kojiro Nagai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/91a4759a73d646a09a3b309417eee090
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