A window of opportunity for cooperativity in the T Cell Receptor

T cells can be activated by a small, two-digit, number of antigen peptide molecules even though the receptor for antigen (TCR) is of low affinity. Here the authors present evidence that all TCRs within a nanocluster can become activated when only a subset is bound to antigen.

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Autores principales:	N. Martin-Blanco, R. Blanco, C. Alda-Catalinas, E. R. Bovolenta, C. L. Oeste, E. Palmer, W. W. Schamel, G. Lythe, C. Molina-París, M. Castro, B. Alarcon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91a95e6f91964a4aa0d2bb86619bfe39
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spelling	oai:doaj.org-article:91a95e6f91964a4aa0d2bb86619bfe392021-12-02T16:56:53ZA window of opportunity for cooperativity in the T Cell Receptor10.1038/s41467-018-05050-62041-1723https://doaj.org/article/91a95e6f91964a4aa0d2bb86619bfe392018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05050-6https://doaj.org/toc/2041-1723T cells can be activated by a small, two-digit, number of antigen peptide molecules even though the receptor for antigen (TCR) is of low affinity. Here the authors present evidence that all TCRs within a nanocluster can become activated when only a subset is bound to antigen.N. Martin-BlancoR. BlancoC. Alda-CatalinasE. R. BovolentaC. L. OesteE. PalmerW. W. SchamelG. LytheC. Molina-ParísM. CastroB. AlarconNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. Martin-Blanco R. Blanco C. Alda-Catalinas E. R. Bovolenta C. L. Oeste E. Palmer W. W. Schamel G. Lythe C. Molina-París M. Castro B. Alarcon A window of opportunity for cooperativity in the T Cell Receptor
description	T cells can be activated by a small, two-digit, number of antigen peptide molecules even though the receptor for antigen (TCR) is of low affinity. Here the authors present evidence that all TCRs within a nanocluster can become activated when only a subset is bound to antigen.
format	article
author	N. Martin-Blanco R. Blanco C. Alda-Catalinas E. R. Bovolenta C. L. Oeste E. Palmer W. W. Schamel G. Lythe C. Molina-París M. Castro B. Alarcon
author_facet	N. Martin-Blanco R. Blanco C. Alda-Catalinas E. R. Bovolenta C. L. Oeste E. Palmer W. W. Schamel G. Lythe C. Molina-París M. Castro B. Alarcon
author_sort	N. Martin-Blanco
title	A window of opportunity for cooperativity in the T Cell Receptor
title_short	A window of opportunity for cooperativity in the T Cell Receptor
title_full	A window of opportunity for cooperativity in the T Cell Receptor
title_fullStr	A window of opportunity for cooperativity in the T Cell Receptor
title_full_unstemmed	A window of opportunity for cooperativity in the T Cell Receptor
title_sort	window of opportunity for cooperativity in the t cell receptor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/91a95e6f91964a4aa0d2bb86619bfe39
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A window of opportunity for cooperativity in the T Cell Receptor

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