A window of opportunity for cooperativity in the T Cell Receptor

T cells can be activated by a small, two-digit, number of antigen peptide molecules even though the receptor for antigen (TCR) is of low affinity. Here the authors present evidence that all TCRs within a nanocluster can become activated when only a subset is bound to antigen.

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Detalles Bibliográficos
Autores principales: N. Martin-Blanco, R. Blanco, C. Alda-Catalinas, E. R. Bovolenta, C. L. Oeste, E. Palmer, W. W. Schamel, G. Lythe, C. Molina-París, M. Castro, B. Alarcon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/91a95e6f91964a4aa0d2bb86619bfe39
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