ANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia

Hana Alahmari,1 Hana Al Daajani,2 Fatimah Alsayed,3 Abdulrhaman Alrashid4 1Rheumatology Unit, Department of Medicine, King Khalid University Hospital, Abha, Saudi Arabia; 2Rheumatology Unit, Department of Medicine, King Fahad Military Medical City, Dammam, Saudi Arabia; 3Department of Medicine, King...

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Autores principales:	Alahmari H, Al Daajani H, Alsayed F, Alrashid A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	anca associated vasculitis relapse predictors bvas low complements rheumatoid factor relapse criteria Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/91ad03b56f104ec58219da44914bf81e
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spelling	oai:doaj.org-article:91ad03b56f104ec58219da44914bf81e2021-12-02T16:43:36ZANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia1179-156Xhttps://doaj.org/article/91ad03b56f104ec58219da44914bf81e2021-07-01T00:00:00Zhttps://www.dovepress.com/anca-associated-vasculitis-clinical-presentation-and-clinical-predicto-peer-reviewed-fulltext-article-OARRRhttps://doaj.org/toc/1179-156XHana Alahmari,1 Hana Al Daajani,2 Fatimah Alsayed,3 Abdulrhaman Alrashid4 1Rheumatology Unit, Department of Medicine, King Khalid University Hospital, Abha, Saudi Arabia; 2Rheumatology Unit, Department of Medicine, King Fahad Military Medical City, Dammam, Saudi Arabia; 3Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia; 4Rheumatology Unit, Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi ArabiaCorrespondence: Hana AlahmariRheumatology Unit, Department of Medicine, King Khalid University Hospital, P.O Box 641, Abha, Saudi ArabiaTel +966 72417578Fax +966 7418111Email Drhana.s@hotmail.comBackground: Anti-neutrophil cytoplasm antibodies-associated vasculitis (AAV) is a rare autoimmune condition with high-relapsing rate and incidence of complications, resulting in increased morbidity and mortality. Characters of patients with anti-neutrophil cytoplasm antibodies-associated vasculitis in Saudi Arabia require further exploration.Objective: To evaluate the clinical profile, relapse rate and disease-related complications among patients with AAV at a tertiary hospital in Saudi Arabia. To estimate the role of BVAS score at the time of presentation in predicting relapse during the disease course.Design and Setting: This retrospective cohort study was performed through data collection from patients’ records who had AAV, who visited the rheumatology clinic. The collected data involved the demographics of patients and their investigations, medications, and outcomes of treatment. Statistical analysis was executed through SPSS version 26.Results: Fifty-two patients were eligible for inclusion, while 48 patients were analyzed because of missing data. Females represented 60.4%. Half of the patients were more than 50 years old, and 68.8% had comorbidities. As for diagnosis, 62.5% had granulomatosis with polyangiitis, 25% had eosinophilic granulomatosis with polyangiitis, and 12.5% had microscopic polyangiitis. The rate of relapse was 31.3%, while the remission rate was 68.8%. Additionally, 66.7% had lower respiratory involvement, and 43.8% had renal involvement. More than half of the patients had BVAS score below 14.5 points. The study did not explore a positive correlation between the disease relapse and high BVAS at the first presentation.Conclusion: Early prediction of relapse and such intervention is of paramount importance in order to avoid accrual of organ damage with treatments that prevent further relapses. BVAS score was not found to be a potential predictor in our study. Future studies are highly endorsed, with prospective design and large sample size to achieve statistical significance for the incidence of relapses and complications.Keywords: ANCA-associated vasculitis, relapse predictors, BVAS, low complements, rheumatoid factor, relapse criteriaAlahmari HAl Daajani HAlsayed FAlrashid ADove Medical Pressarticleanca associated vasculitisrelapse predictorsbvaslow complementsrheumatoid factorrelapse criteriaDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 13, Pp 213-220 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anca associated vasculitis relapse predictors bvas low complements rheumatoid factor relapse criteria Diseases of the musculoskeletal system RC925-935
spellingShingle	anca associated vasculitis relapse predictors bvas low complements rheumatoid factor relapse criteria Diseases of the musculoskeletal system RC925-935 Alahmari H Al Daajani H Alsayed F Alrashid A ANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia
description	Hana Alahmari,1 Hana Al Daajani,2 Fatimah Alsayed,3 Abdulrhaman Alrashid4 1Rheumatology Unit, Department of Medicine, King Khalid University Hospital, Abha, Saudi Arabia; 2Rheumatology Unit, Department of Medicine, King Fahad Military Medical City, Dammam, Saudi Arabia; 3Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia; 4Rheumatology Unit, Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi ArabiaCorrespondence: Hana AlahmariRheumatology Unit, Department of Medicine, King Khalid University Hospital, P.O Box 641, Abha, Saudi ArabiaTel +966 72417578Fax +966 7418111Email Drhana.s@hotmail.comBackground: Anti-neutrophil cytoplasm antibodies-associated vasculitis (AAV) is a rare autoimmune condition with high-relapsing rate and incidence of complications, resulting in increased morbidity and mortality. Characters of patients with anti-neutrophil cytoplasm antibodies-associated vasculitis in Saudi Arabia require further exploration.Objective: To evaluate the clinical profile, relapse rate and disease-related complications among patients with AAV at a tertiary hospital in Saudi Arabia. To estimate the role of BVAS score at the time of presentation in predicting relapse during the disease course.Design and Setting: This retrospective cohort study was performed through data collection from patients’ records who had AAV, who visited the rheumatology clinic. The collected data involved the demographics of patients and their investigations, medications, and outcomes of treatment. Statistical analysis was executed through SPSS version 26.Results: Fifty-two patients were eligible for inclusion, while 48 patients were analyzed because of missing data. Females represented 60.4%. Half of the patients were more than 50 years old, and 68.8% had comorbidities. As for diagnosis, 62.5% had granulomatosis with polyangiitis, 25% had eosinophilic granulomatosis with polyangiitis, and 12.5% had microscopic polyangiitis. The rate of relapse was 31.3%, while the remission rate was 68.8%. Additionally, 66.7% had lower respiratory involvement, and 43.8% had renal involvement. More than half of the patients had BVAS score below 14.5 points. The study did not explore a positive correlation between the disease relapse and high BVAS at the first presentation.Conclusion: Early prediction of relapse and such intervention is of paramount importance in order to avoid accrual of organ damage with treatments that prevent further relapses. BVAS score was not found to be a potential predictor in our study. Future studies are highly endorsed, with prospective design and large sample size to achieve statistical significance for the incidence of relapses and complications.Keywords: ANCA-associated vasculitis, relapse predictors, BVAS, low complements, rheumatoid factor, relapse criteria
format	article
author	Alahmari H Al Daajani H Alsayed F Alrashid A
author_facet	Alahmari H Al Daajani H Alsayed F Alrashid A
author_sort	Alahmari H
title	ANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia
title_short	ANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia
title_full	ANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia
title_fullStr	ANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia
title_full_unstemmed	ANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia
title_sort	anca-associated vasculitis clinical presentation and clinical predictors of relapse in saudi arabia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/91ad03b56f104ec58219da44914bf81e
work_keys_str_mv	AT alahmarih ancaassociatedvasculitisclinicalpresentationandclinicalpredictorsofrelapseinsaudiarabia AT aldaajanih ancaassociatedvasculitisclinicalpresentationandclinicalpredictorsofrelapseinsaudiarabia AT alsayedf ancaassociatedvasculitisclinicalpresentationandclinicalpredictorsofrelapseinsaudiarabia AT alrashida ancaassociatedvasculitisclinicalpresentationandclinicalpredictorsofrelapseinsaudiarabia
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ANCA-Associated Vasculitis Clinical Presentation and Clinical Predictors of Relapse in Saudi Arabia

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