Genome maps across 26 human populations reveal population-specific patterns of structural variation

Large structural variants (SV) are understudied in human genetics research because of the difficulty to detect them in the routinely generated short-read sequencing data. Here, the authors generate optical genome maps of 154 individuals from 26 populations that allow comprehensive examination of lar...

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Autores principales:	Michal Levy-Sakin, Steven Pastor, Yulia Mostovoy, Le Li, Alden K. Y. Leung, Jennifer McCaffrey, Eleanor Young, Ernest T. Lam, Alex R. Hastie, Karen H. Y. Wong, Claire Y. L. Chung, Walfred Ma, Justin Sibert, Ramakrishnan Rajagopalan, Nana Jin, Eugene Y. C. Chow, Catherine Chu, Annie Poon, Chin Lin, Ahmed Naguib, Wei-Ping Wang, Han Cao, Ting-Fung Chan, Kevin Y. Yip, Ming Xiao, Pui-Yan Kwok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91ad69cc6ebb4dd28ba0a08624df46fd
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spelling	oai:doaj.org-article:91ad69cc6ebb4dd28ba0a08624df46fd2021-12-02T16:58:05ZGenome maps across 26 human populations reveal population-specific patterns of structural variation10.1038/s41467-019-08992-72041-1723https://doaj.org/article/91ad69cc6ebb4dd28ba0a08624df46fd2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08992-7https://doaj.org/toc/2041-1723Large structural variants (SV) are understudied in human genetics research because of the difficulty to detect them in the routinely generated short-read sequencing data. Here, the authors generate optical genome maps of 154 individuals from 26 populations that allow comprehensive examination of large SVs.Michal Levy-SakinSteven PastorYulia MostovoyLe LiAlden K. Y. LeungJennifer McCaffreyEleanor YoungErnest T. LamAlex R. HastieKaren H. Y. WongClaire Y. L. ChungWalfred MaJustin SibertRamakrishnan RajagopalanNana JinEugene Y. C. ChowCatherine ChuAnnie PoonChin LinAhmed NaguibWei-Ping WangHan CaoTing-Fung ChanKevin Y. YipMing XiaoPui-Yan KwokNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michal Levy-Sakin Steven Pastor Yulia Mostovoy Le Li Alden K. Y. Leung Jennifer McCaffrey Eleanor Young Ernest T. Lam Alex R. Hastie Karen H. Y. Wong Claire Y. L. Chung Walfred Ma Justin Sibert Ramakrishnan Rajagopalan Nana Jin Eugene Y. C. Chow Catherine Chu Annie Poon Chin Lin Ahmed Naguib Wei-Ping Wang Han Cao Ting-Fung Chan Kevin Y. Yip Ming Xiao Pui-Yan Kwok Genome maps across 26 human populations reveal population-specific patterns of structural variation
description	Large structural variants (SV) are understudied in human genetics research because of the difficulty to detect them in the routinely generated short-read sequencing data. Here, the authors generate optical genome maps of 154 individuals from 26 populations that allow comprehensive examination of large SVs.
format	article
author	Michal Levy-Sakin Steven Pastor Yulia Mostovoy Le Li Alden K. Y. Leung Jennifer McCaffrey Eleanor Young Ernest T. Lam Alex R. Hastie Karen H. Y. Wong Claire Y. L. Chung Walfred Ma Justin Sibert Ramakrishnan Rajagopalan Nana Jin Eugene Y. C. Chow Catherine Chu Annie Poon Chin Lin Ahmed Naguib Wei-Ping Wang Han Cao Ting-Fung Chan Kevin Y. Yip Ming Xiao Pui-Yan Kwok
author_facet	Michal Levy-Sakin Steven Pastor Yulia Mostovoy Le Li Alden K. Y. Leung Jennifer McCaffrey Eleanor Young Ernest T. Lam Alex R. Hastie Karen H. Y. Wong Claire Y. L. Chung Walfred Ma Justin Sibert Ramakrishnan Rajagopalan Nana Jin Eugene Y. C. Chow Catherine Chu Annie Poon Chin Lin Ahmed Naguib Wei-Ping Wang Han Cao Ting-Fung Chan Kevin Y. Yip Ming Xiao Pui-Yan Kwok
author_sort	Michal Levy-Sakin
title	Genome maps across 26 human populations reveal population-specific patterns of structural variation
title_short	Genome maps across 26 human populations reveal population-specific patterns of structural variation
title_full	Genome maps across 26 human populations reveal population-specific patterns of structural variation
title_fullStr	Genome maps across 26 human populations reveal population-specific patterns of structural variation
title_full_unstemmed	Genome maps across 26 human populations reveal population-specific patterns of structural variation
title_sort	genome maps across 26 human populations reveal population-specific patterns of structural variation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/91ad69cc6ebb4dd28ba0a08624df46fd
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Genome maps across 26 human populations reveal population-specific patterns of structural variation

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