Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study

Introduction: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neuroc...

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Autores principales:	Oana M. Dumitrascu, Ryan Rosenberry, Dale S. Sherman, Maziyar M. Khansari, Julia Sheyn, Tania Torbati, Ayesha Sherzai, Dean Sherzai, Kenneth O. Johnson, Alan D. Czeszynski, Steven Verdooner, Keith L. Black, Sally Frautschy, Patrick D. Lyden, Yonggang Shi, Susan Cheng, Yosef Koronyo, Maya Koronyo-Hamaoui
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	retinopathy retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/91af713ab8eb49d9acfd6ded438d5810
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spelling	oai:doaj.org-article:91af713ab8eb49d9acfd6ded438d58102021-11-25T17:09:01ZRetinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study10.3390/cells101129262073-4409https://doaj.org/article/91af713ab8eb49d9acfd6ded438d58102021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2926https://doaj.org/toc/2073-4409Introduction: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neurocognitive status. Methods: We used quantitative RFI in a cohort of patients with cognitive impairment to automatically compute retinal amyloid burden. Retinal blood vessels were segmented, and the vessel tortuosity index (VTI), inflection index, and branching angle were quantified. We assessed the correlations between retinal vascular and amyloid parameters, and cognitive domain Z-scores using linear regression models. Results: Thirty-four subjects were enrolled and twenty-nine (55% female, mean age 64 ± 6 years) were included in the combined retinal amyloid and vascular analysis. Eleven subjects had normal cognition and 18 had impaired cognition. Retinal VTI was discriminated among cognitive scores. The combined proximal mid-periphery amyloid count and venous VTI index exhibited significant differences between cognitively impaired and cognitively normal subjects (0.49 ± 1.1 vs. 0.91 ± 1.4, <i>p</i> = 0.006), and correlated with both the Wechsler Memory Scale-IV and SF-36 mental component score Z-scores (<i>p</i> < 0.05). Conclusion: This pilot study showed that retinal venular VTI combined with the proximal mid-periphery amyloid count could predict verbal memory loss. Future research is needed to finesse the clinical application of this retinal imaging-based technology.Oana M. DumitrascuRyan RosenberryDale S. ShermanMaziyar M. KhansariJulia SheynTania TorbatiAyesha SherzaiDean SherzaiKenneth O. JohnsonAlan D. CzeszynskiSteven VerdoonerKeith L. BlackSally FrautschyPatrick D. LydenYonggang ShiSusan ChengYosef KoronyoMaya Koronyo-HamaouiMDPI AGarticleretinopathyretinal vesselsretinal fluorescence imagingamyloidcognitive declineAlzheimer’s diseaseBiology (General)QH301-705.5ENCells, Vol 10, Iss 2926, p 2926 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinopathy retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease Biology (General) QH301-705.5
spellingShingle	retinopathy retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease Biology (General) QH301-705.5 Oana M. Dumitrascu Ryan Rosenberry Dale S. Sherman Maziyar M. Khansari Julia Sheyn Tania Torbati Ayesha Sherzai Dean Sherzai Kenneth O. Johnson Alan D. Czeszynski Steven Verdooner Keith L. Black Sally Frautschy Patrick D. Lyden Yonggang Shi Susan Cheng Yosef Koronyo Maya Koronyo-Hamaoui Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study
description	Introduction: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neurocognitive status. Methods: We used quantitative RFI in a cohort of patients with cognitive impairment to automatically compute retinal amyloid burden. Retinal blood vessels were segmented, and the vessel tortuosity index (VTI), inflection index, and branching angle were quantified. We assessed the correlations between retinal vascular and amyloid parameters, and cognitive domain Z-scores using linear regression models. Results: Thirty-four subjects were enrolled and twenty-nine (55% female, mean age 64 ± 6 years) were included in the combined retinal amyloid and vascular analysis. Eleven subjects had normal cognition and 18 had impaired cognition. Retinal VTI was discriminated among cognitive scores. The combined proximal mid-periphery amyloid count and venous VTI index exhibited significant differences between cognitively impaired and cognitively normal subjects (0.49 ± 1.1 vs. 0.91 ± 1.4, <i>p</i> = 0.006), and correlated with both the Wechsler Memory Scale-IV and SF-36 mental component score Z-scores (<i>p</i> < 0.05). Conclusion: This pilot study showed that retinal venular VTI combined with the proximal mid-periphery amyloid count could predict verbal memory loss. Future research is needed to finesse the clinical application of this retinal imaging-based technology.
format	article
author	Oana M. Dumitrascu Ryan Rosenberry Dale S. Sherman Maziyar M. Khansari Julia Sheyn Tania Torbati Ayesha Sherzai Dean Sherzai Kenneth O. Johnson Alan D. Czeszynski Steven Verdooner Keith L. Black Sally Frautschy Patrick D. Lyden Yonggang Shi Susan Cheng Yosef Koronyo Maya Koronyo-Hamaoui
author_facet	Oana M. Dumitrascu Ryan Rosenberry Dale S. Sherman Maziyar M. Khansari Julia Sheyn Tania Torbati Ayesha Sherzai Dean Sherzai Kenneth O. Johnson Alan D. Czeszynski Steven Verdooner Keith L. Black Sally Frautschy Patrick D. Lyden Yonggang Shi Susan Cheng Yosef Koronyo Maya Koronyo-Hamaoui
author_sort	Oana M. Dumitrascu
title	Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study
title_short	Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study
title_full	Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study
title_fullStr	Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study
title_full_unstemmed	Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study
title_sort	retinal venular tortuosity jointly with retinal amyloid burden correlates with verbal memory loss: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/91af713ab8eb49d9acfd6ded438d5810
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Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study

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