In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.

CD4(+) T cells display a variety of helper functions necessary for an efficient adaptive immune response against bacterial invaders. This work reports the in vivo identification and characterization of murine cytotoxic CD4(+) T cells (CD4(+) CTL) during Brucella abortus infection. These CD4(+) CTLs...

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Autores principales:	Anna Martirosyan, Kristine Von Bargen, Vilma Arce Gorvel, Weidong Zhao, Sean Hanniffy, Johnny Bonnardel, Stéphane Méresse, Jean-Pierre Gorvel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91afeb5624744cf894d289afe9023561
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spelling	oai:doaj.org-article:91afeb5624744cf894d289afe90235612021-11-18T08:41:11ZIn vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.1932-620310.1371/journal.pone.0082508https://doaj.org/article/91afeb5624744cf894d289afe90235612013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24367519/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203CD4(+) T cells display a variety of helper functions necessary for an efficient adaptive immune response against bacterial invaders. This work reports the in vivo identification and characterization of murine cytotoxic CD4(+) T cells (CD4(+) CTL) during Brucella abortus infection. These CD4(+) CTLs express granzyme B and exhibit immunophenotypic features consistent with fully differentiated T cells. They express CD25, CD44, CD62L ,CD43 molecules at their surface and produce IFN-γ. Moreover, these cells express neither the co-stimulatory molecule CD27 nor the memory T cell marker CD127. We show here that CD4(+) CTLs are capable of cytolytic action against Brucella-infected antigen presenting cells (APC) but not against Mycobacterium-infected APC. Cytotoxic CD4(+) T cell population appears at early stages of the infection concomitantly with high levels of IFN-γ and granzyme B expression. CD4(+) CTLs represent a so far uncharacterized immune cell sub-type triggered by early immune responses upon Brucella abortus infection.Anna MartirosyanKristine Von BargenVilma Arce GorvelWeidong ZhaoSean HanniffyJohnny BonnardelStéphane MéresseJean-Pierre GorvelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82508 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Martirosyan Kristine Von Bargen Vilma Arce Gorvel Weidong Zhao Sean Hanniffy Johnny Bonnardel Stéphane Méresse Jean-Pierre Gorvel In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.
description	CD4(+) T cells display a variety of helper functions necessary for an efficient adaptive immune response against bacterial invaders. This work reports the in vivo identification and characterization of murine cytotoxic CD4(+) T cells (CD4(+) CTL) during Brucella abortus infection. These CD4(+) CTLs express granzyme B and exhibit immunophenotypic features consistent with fully differentiated T cells. They express CD25, CD44, CD62L ,CD43 molecules at their surface and produce IFN-γ. Moreover, these cells express neither the co-stimulatory molecule CD27 nor the memory T cell marker CD127. We show here that CD4(+) CTLs are capable of cytolytic action against Brucella-infected antigen presenting cells (APC) but not against Mycobacterium-infected APC. Cytotoxic CD4(+) T cell population appears at early stages of the infection concomitantly with high levels of IFN-γ and granzyme B expression. CD4(+) CTLs represent a so far uncharacterized immune cell sub-type triggered by early immune responses upon Brucella abortus infection.
format	article
author	Anna Martirosyan Kristine Von Bargen Vilma Arce Gorvel Weidong Zhao Sean Hanniffy Johnny Bonnardel Stéphane Méresse Jean-Pierre Gorvel
author_facet	Anna Martirosyan Kristine Von Bargen Vilma Arce Gorvel Weidong Zhao Sean Hanniffy Johnny Bonnardel Stéphane Méresse Jean-Pierre Gorvel
author_sort	Anna Martirosyan
title	In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.
title_short	In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.
title_full	In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.
title_fullStr	In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.
title_full_unstemmed	In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.
title_sort	in vivo identification and characterization of cd4⁺ cytotoxic t cells induced by virulent brucella abortus infection.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/91afeb5624744cf894d289afe9023561
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_version_	1718421458644893696

In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.

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