Uveal metastases in the mid-southeastern United States: a single-institution experience

 Benjamin A King1,2 Elizabeth U Rosenberger,1 Vanessa M Morales-Tirado,1,3 Matthew W Wilson1,2 1Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA; 2Department of Surgery, St Jude Children’s Re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	King BA, Rosenberger EU, Morales-Tirado VM, Wilson MW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	uveal metastasis cancer epidemiology Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/91b0074592644e96a24be57cd34beed3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:91b0074592644e96a24be57cd34beed3
record_format	dspace
spelling	oai:doaj.org-article:91b0074592644e96a24be57cd34beed32021-12-02T06:11:34ZUveal metastases in the mid-southeastern United States: a single-institution experience1177-5483https://doaj.org/article/91b0074592644e96a24be57cd34beed32018-08-01T00:00:00Zhttps://www.dovepress.com/uveal-metastases-in-the-mid-southeastern-united-states-a-single-instit-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Benjamin A King1,2 Elizabeth U Rosenberger,1 Vanessa M Morales-Tirado,1,3 Matthew W Wilson1,2 1Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA; 2Department of Surgery, St Jude Children’s Research Hospital, Memphis, TN, USA; 3Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA Purpose: To report the clinical features of uveal metastases in a geographic region associated with high tobacco use. Methods: Medical records from all patients diagnosed with uveal metastasis at a single tertiary referral center between 2000 and 2017 were retrospectively reviewed. The clinical features and the primary tumor site associated with each metastatic lesion were recorded. Results: Ninety-nine uveal metastatic tumors were identified in 85 eyes of 74 patients (34 males). Median age at diagnosis was 62 years. Median tumor diameter was 11.6 mm and median height was 3.1 mm. Carcinoma of the lung was the most common primary tumor occurring in 37 patients (50%) followed by breast in 16 patients (21%). Among females, metastatic lesions originated from the lung in 18 patients and from the breast in 16 patients. Median survival following intraocular metastasis was 9 months for patients with a primary lung malignancy and 36 months for patients with breast cancer (log-rank test, P=0.002).Conclusion: Intraocular metastasis is more frequently observed in patients with carcinomas of the lung rather than breast at our treatment center. Both regional and global changes in cancer epidemiology most likely account for the findings in this study.Keywords: iris, choroid, cancer, metastases, lung, breast, eyeKing BARosenberger EUMorales-Tirado VMWilson MWDove Medical Pressarticleuveal metastasiscancer epidemiologyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1459-1463 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	uveal metastasis cancer epidemiology Ophthalmology RE1-994
spellingShingle	uveal metastasis cancer epidemiology Ophthalmology RE1-994 King BA Rosenberger EU Morales-Tirado VM Wilson MW Uveal metastases in the mid-southeastern United States: a single-institution experience
description	Benjamin A King1,2 Elizabeth U Rosenberger,1 Vanessa M Morales-Tirado,1,3 Matthew W Wilson1,2 1Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA; 2Department of Surgery, St Jude Children’s Research Hospital, Memphis, TN, USA; 3Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA Purpose: To report the clinical features of uveal metastases in a geographic region associated with high tobacco use. Methods: Medical records from all patients diagnosed with uveal metastasis at a single tertiary referral center between 2000 and 2017 were retrospectively reviewed. The clinical features and the primary tumor site associated with each metastatic lesion were recorded. Results: Ninety-nine uveal metastatic tumors were identified in 85 eyes of 74 patients (34 males). Median age at diagnosis was 62 years. Median tumor diameter was 11.6 mm and median height was 3.1 mm. Carcinoma of the lung was the most common primary tumor occurring in 37 patients (50%) followed by breast in 16 patients (21%). Among females, metastatic lesions originated from the lung in 18 patients and from the breast in 16 patients. Median survival following intraocular metastasis was 9 months for patients with a primary lung malignancy and 36 months for patients with breast cancer (log-rank test, P=0.002).Conclusion: Intraocular metastasis is more frequently observed in patients with carcinomas of the lung rather than breast at our treatment center. Both regional and global changes in cancer epidemiology most likely account for the findings in this study.Keywords: iris, choroid, cancer, metastases, lung, breast, eye
format	article
author	King BA Rosenberger EU Morales-Tirado VM Wilson MW
author_facet	King BA Rosenberger EU Morales-Tirado VM Wilson MW
author_sort	King BA
title	Uveal metastases in the mid-southeastern United States: a single-institution experience
title_short	Uveal metastases in the mid-southeastern United States: a single-institution experience
title_full	Uveal metastases in the mid-southeastern United States: a single-institution experience
title_fullStr	Uveal metastases in the mid-southeastern United States: a single-institution experience
title_full_unstemmed	Uveal metastases in the mid-southeastern United States: a single-institution experience
title_sort	uveal metastases in the mid-southeastern united states: a single-institution experience
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/91b0074592644e96a24be57cd34beed3
work_keys_str_mv	AT kingba uvealmetastasesinthemidsoutheasternunitedstatesasingleinstitutionexperience AT rosenbergereu uvealmetastasesinthemidsoutheasternunitedstatesasingleinstitutionexperience AT moralestiradovm uvealmetastasesinthemidsoutheasternunitedstatesasingleinstitutionexperience AT wilsonmw uvealmetastasesinthemidsoutheasternunitedstatesasingleinstitutionexperience
_version_	1718400064961904640

Uveal metastases in the mid-southeastern United States: a single-institution experience

Ejemplares similares