Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity

Epithelial subpopulations are present in the human breast but how these differentiate or form is unclear. Here, the authors use single-cell RNA sequencing of primary human breast epithelial cells to define previously undescribed luminal, basal epithelial subpopulations and ZEB1-positive basal cells.

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Autores principales:	Quy H. Nguyen, Nicholas Pervolarakis, Kerrigan Blake, Dennis Ma, Ryan Tevia Davis, Nathan James, Anh T. Phung, Elizabeth Willey, Raj Kumar, Eric Jabart, Ian Driver, Jason Rock, Andrei Goga, Seema A. Khan, Devon A. Lawson, Zena Werb, Kai Kessenbrock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91b73d5c18954375862a70796e2fa7c2
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spelling	oai:doaj.org-article:91b73d5c18954375862a70796e2fa7c22021-12-02T15:34:44ZProfiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity10.1038/s41467-018-04334-12041-1723https://doaj.org/article/91b73d5c18954375862a70796e2fa7c22018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04334-1https://doaj.org/toc/2041-1723Epithelial subpopulations are present in the human breast but how these differentiate or form is unclear. Here, the authors use single-cell RNA sequencing of primary human breast epithelial cells to define previously undescribed luminal, basal epithelial subpopulations and ZEB1-positive basal cells.Quy H. NguyenNicholas PervolarakisKerrigan BlakeDennis MaRyan Tevia DavisNathan JamesAnh T. PhungElizabeth WilleyRaj KumarEric JabartIan DriverJason RockAndrei GogaSeema A. KhanDevon A. LawsonZena WerbKai KessenbrockNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Quy H. Nguyen Nicholas Pervolarakis Kerrigan Blake Dennis Ma Ryan Tevia Davis Nathan James Anh T. Phung Elizabeth Willey Raj Kumar Eric Jabart Ian Driver Jason Rock Andrei Goga Seema A. Khan Devon A. Lawson Zena Werb Kai Kessenbrock Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
description	Epithelial subpopulations are present in the human breast but how these differentiate or form is unclear. Here, the authors use single-cell RNA sequencing of primary human breast epithelial cells to define previously undescribed luminal, basal epithelial subpopulations and ZEB1-positive basal cells.
format	article
author	Quy H. Nguyen Nicholas Pervolarakis Kerrigan Blake Dennis Ma Ryan Tevia Davis Nathan James Anh T. Phung Elizabeth Willey Raj Kumar Eric Jabart Ian Driver Jason Rock Andrei Goga Seema A. Khan Devon A. Lawson Zena Werb Kai Kessenbrock
author_facet	Quy H. Nguyen Nicholas Pervolarakis Kerrigan Blake Dennis Ma Ryan Tevia Davis Nathan James Anh T. Phung Elizabeth Willey Raj Kumar Eric Jabart Ian Driver Jason Rock Andrei Goga Seema A. Khan Devon A. Lawson Zena Werb Kai Kessenbrock
author_sort	Quy H. Nguyen
title	Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
title_short	Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
title_full	Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
title_fullStr	Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
title_full_unstemmed	Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
title_sort	profiling human breast epithelial cells using single cell rna sequencing identifies cell diversity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/91b73d5c18954375862a70796e2fa7c2
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Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity

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