Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

Treatment options for metastatic melanoma are limited. Here the authors show that combining an immunostimulant adenovirus, currently in clinical trials for leukemia, with immune checkpoints blockade (ICB) results in systemic eradication of ICB resistant melanoma tumours from both skin and brain of m...

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Autores principales: Manisha Singh, Christina Vianden, Mark J. Cantwell, Zhimin Dai, Zhilan Xiao, Meenu Sharma, Hiep Khong, Ashvin R. Jaiswal, Faisal Faak, Yared Hailemichael, L. M. E. Janssen, Uddalak Bharadwaj, Michael A. Curran, Adi Diab, Roland L. Bassett, David J. Tweardy, Patrick Hwu, Willem W. Overwijk
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/91b84c7ca48048a5926a4f18a85bbaa3
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Sumario:Treatment options for metastatic melanoma are limited. Here the authors show that combining an immunostimulant adenovirus, currently in clinical trials for leukemia, with immune checkpoints blockade (ICB) results in systemic eradication of ICB resistant melanoma tumours from both skin and brain of mice.

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