Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

Treatment options for metastatic melanoma are limited. Here the authors show that combining an immunostimulant adenovirus, currently in clinical trials for leukemia, with immune checkpoints blockade (ICB) results in systemic eradication of ICB resistant melanoma tumours from both skin and brain of m...

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Autores principales:	Manisha Singh, Christina Vianden, Mark J. Cantwell, Zhimin Dai, Zhilan Xiao, Meenu Sharma, Hiep Khong, Ashvin R. Jaiswal, Faisal Faak, Yared Hailemichael, L. M. E. Janssen, Uddalak Bharadwaj, Michael A. Curran, Adi Diab, Roland L. Bassett, David J. Tweardy, Patrick Hwu, Willem W. Overwijk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91b84c7ca48048a5926a4f18a85bbaa3
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spelling	oai:doaj.org-article:91b84c7ca48048a5926a4f18a85bbaa32021-12-02T17:06:13ZIntratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain10.1038/s41467-017-01572-72041-1723https://doaj.org/article/91b84c7ca48048a5926a4f18a85bbaa32017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01572-7https://doaj.org/toc/2041-1723Treatment options for metastatic melanoma are limited. Here the authors show that combining an immunostimulant adenovirus, currently in clinical trials for leukemia, with immune checkpoints blockade (ICB) results in systemic eradication of ICB resistant melanoma tumours from both skin and brain of mice.Manisha SinghChristina ViandenMark J. CantwellZhimin DaiZhilan XiaoMeenu SharmaHiep KhongAshvin R. JaiswalFaisal FaakYared HailemichaelL. M. E. JanssenUddalak BharadwajMichael A. CurranAdi DiabRoland L. BassettDavid J. TweardyPatrick HwuWillem W. OverwijkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manisha Singh Christina Vianden Mark J. Cantwell Zhimin Dai Zhilan Xiao Meenu Sharma Hiep Khong Ashvin R. Jaiswal Faisal Faak Yared Hailemichael L. M. E. Janssen Uddalak Bharadwaj Michael A. Curran Adi Diab Roland L. Bassett David J. Tweardy Patrick Hwu Willem W. Overwijk Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
description	Treatment options for metastatic melanoma are limited. Here the authors show that combining an immunostimulant adenovirus, currently in clinical trials for leukemia, with immune checkpoints blockade (ICB) results in systemic eradication of ICB resistant melanoma tumours from both skin and brain of mice.
format	article
author	Manisha Singh Christina Vianden Mark J. Cantwell Zhimin Dai Zhilan Xiao Meenu Sharma Hiep Khong Ashvin R. Jaiswal Faisal Faak Yared Hailemichael L. M. E. Janssen Uddalak Bharadwaj Michael A. Curran Adi Diab Roland L. Bassett David J. Tweardy Patrick Hwu Willem W. Overwijk
author_facet	Manisha Singh Christina Vianden Mark J. Cantwell Zhimin Dai Zhilan Xiao Meenu Sharma Hiep Khong Ashvin R. Jaiswal Faisal Faak Yared Hailemichael L. M. E. Janssen Uddalak Bharadwaj Michael A. Curran Adi Diab Roland L. Bassett David J. Tweardy Patrick Hwu Willem W. Overwijk
author_sort	Manisha Singh
title	Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
title_short	Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
title_full	Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
title_fullStr	Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
title_full_unstemmed	Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
title_sort	intratumoral cd40 activation and checkpoint blockade induces t cell-mediated eradication of melanoma in the brain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/91b84c7ca48048a5926a4f18a85bbaa3
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Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

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