p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA receptor trafficking during synaptic plasticity.

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Autores principales:	Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jürgen Kast, Jie Lu, Yu Tian Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91ba58e4597d42e5bf8e2615db1d73f1
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spelling	oai:doaj.org-article:91ba58e4597d42e5bf8e2615db1d73f12021-12-02T16:57:20Zp97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression10.1038/s41467-019-12096-72041-1723https://doaj.org/article/91ba58e4597d42e5bf8e2615db1d73f12019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12096-7https://doaj.org/toc/2041-1723AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA receptor trafficking during synaptic plasticity.Yuan GeMeng TianLidong LiuTak Pan WongBo GongDongchuan WuTaesup ChoShujun LinJürgen KastJie LuYu Tian WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Ge Meng Tian Lidong Liu Tak Pan Wong Bo Gong Dongchuan Wu Taesup Cho Shujun Lin Jürgen Kast Jie Lu Yu Tian Wang p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
description	AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA receptor trafficking during synaptic plasticity.
format	article
author	Yuan Ge Meng Tian Lidong Liu Tak Pan Wong Bo Gong Dongchuan Wu Taesup Cho Shujun Lin Jürgen Kast Jie Lu Yu Tian Wang
author_facet	Yuan Ge Meng Tian Lidong Liu Tak Pan Wong Bo Gong Dongchuan Wu Taesup Cho Shujun Lin Jürgen Kast Jie Lu Yu Tian Wang
author_sort	Yuan Ge
title	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_short	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_full	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_fullStr	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_full_unstemmed	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_sort	p97 regulates glua1 homomeric ampa receptor formation and plasma membrane expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/91ba58e4597d42e5bf8e2615db1d73f1
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p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

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