p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA receptor trafficking during synaptic plasticity.

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Autores principales: Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jürgen Kast, Jie Lu, Yu Tian Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/91ba58e4597d42e5bf8e2615db1d73f1
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