In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology,...

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Autores principales:	Guilherme Ribeiro Romualdo, Kaat Leroy, Cícero Júlio Silva Costa, Gabriel Bacil Prata, Bart Vanderborght, Tereza Cristina da Silva, Luís Fernando Barbisan, Wellington Andraus, Lindsey Devisscher, Niels Olsen Saraiva Câmara, Mathieu Vinken, Bruno Cogliati
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocarcinogenesis liver cancer animal model cell culture gene mutation epigenetic alteration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/91bcbda415674b97aaf077363f4732ed
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spelling	oai:doaj.org-article:91bcbda415674b97aaf077363f4732ed2021-11-11T15:36:04ZIn Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling10.3390/cancers132155832072-6694https://doaj.org/article/91bcbda415674b97aaf077363f4732ed2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5583https://doaj.org/toc/2072-6694Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology, mainly caused by chronic hepatitis B and C virus infections, chronic alcohol consumption, aflatoxin-contaminated food, and non-alcoholic fatty liver disease associated with metabolic syndrome or <i>diabetes mellitus</i>. The establishment of HCC models has become essential for both basic and translational research to improve our understanding of the pathophysiology and unravel new molecular drivers of this disease. The ideal model should recapitulate key events observed during hepatocarcinogenesis and HCC progression in view of establishing effective diagnostic and therapeutic strategies to be translated into clinical practice. Despite considerable efforts currently devoted to liver cancer research, only a few anti-HCC drugs are available, and patient prognosis and survival are still poor. The present paper provides a state-of-the-art overview of in vivo and in vitro models used for translational modeling of HCC with a specific focus on their key molecular hallmarks.Guilherme Ribeiro RomualdoKaat LeroyCícero Júlio Silva CostaGabriel Bacil PrataBart VanderborghtTereza Cristina da SilvaLuís Fernando BarbisanWellington AndrausLindsey DevisscherNiels Olsen Saraiva CâmaraMathieu VinkenBruno CogliatiMDPI AGarticlehepatocarcinogenesisliver canceranimal modelcell culturegene mutationepigenetic alterationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5583, p 5583 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocarcinogenesis liver cancer animal model cell culture gene mutation epigenetic alteration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocarcinogenesis liver cancer animal model cell culture gene mutation epigenetic alteration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Guilherme Ribeiro Romualdo Kaat Leroy Cícero Júlio Silva Costa Gabriel Bacil Prata Bart Vanderborght Tereza Cristina da Silva Luís Fernando Barbisan Wellington Andraus Lindsey Devisscher Niels Olsen Saraiva Câmara Mathieu Vinken Bruno Cogliati In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling
description	Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology, mainly caused by chronic hepatitis B and C virus infections, chronic alcohol consumption, aflatoxin-contaminated food, and non-alcoholic fatty liver disease associated with metabolic syndrome or <i>diabetes mellitus</i>. The establishment of HCC models has become essential for both basic and translational research to improve our understanding of the pathophysiology and unravel new molecular drivers of this disease. The ideal model should recapitulate key events observed during hepatocarcinogenesis and HCC progression in view of establishing effective diagnostic and therapeutic strategies to be translated into clinical practice. Despite considerable efforts currently devoted to liver cancer research, only a few anti-HCC drugs are available, and patient prognosis and survival are still poor. The present paper provides a state-of-the-art overview of in vivo and in vitro models used for translational modeling of HCC with a specific focus on their key molecular hallmarks.
format	article
author	Guilherme Ribeiro Romualdo Kaat Leroy Cícero Júlio Silva Costa Gabriel Bacil Prata Bart Vanderborght Tereza Cristina da Silva Luís Fernando Barbisan Wellington Andraus Lindsey Devisscher Niels Olsen Saraiva Câmara Mathieu Vinken Bruno Cogliati
author_facet	Guilherme Ribeiro Romualdo Kaat Leroy Cícero Júlio Silva Costa Gabriel Bacil Prata Bart Vanderborght Tereza Cristina da Silva Luís Fernando Barbisan Wellington Andraus Lindsey Devisscher Niels Olsen Saraiva Câmara Mathieu Vinken Bruno Cogliati
author_sort	Guilherme Ribeiro Romualdo
title	In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling
title_short	In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling
title_full	In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling
title_fullStr	In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling
title_full_unstemmed	In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling
title_sort	in vivo and in vitro models of hepatocellular carcinoma: current strategies for translational modeling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/91bcbda415674b97aaf077363f4732ed
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In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling

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