Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects

Tianze Cheng,1 Dominique Marie Wallace,2 Benjamin Ponteri,1 Mahir Tuli3 1Pitzer College, Claremont, CA, USA; 2Portland State University, Portland, OR, USA; 3University of British Columbia, Vancouver, BC, Canada Abstract: Benzodiazepines are one of the most prescribed medications as first-line trea...

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Autores principales:	Cheng T, Wallace DM, Ponteri B, Tuli M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Benzodiazepines Subtype Tolerance Dependence Anxiolytic GABAA receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/91bd194a589f4a8490c8b2d796931f6f
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spelling	oai:doaj.org-article:91bd194a589f4a8490c8b2d796931f6f2021-12-02T03:18:11ZValium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects1178-2021https://doaj.org/article/91bd194a589f4a8490c8b2d796931f6f2018-05-01T00:00:00Zhttps://www.dovepress.com/valium-without-dependence-individual-gabaa-receptor-subtype-contributi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tianze Cheng,1 Dominique Marie Wallace,2 Benjamin Ponteri,1 Mahir Tuli3 1Pitzer College, Claremont, CA, USA; 2Portland State University, Portland, OR, USA; 3University of British Columbia, Vancouver, BC, Canada Abstract: Benzodiazepines are one of the most prescribed medications as first-line treatment of anxiety, insomnia, and epilepsy around the world. Over the past two decades, advances in the neuropharmacological understanding of gamma aminobutyric acid (GABA)A receptors revealed distinct contributions from each subtype and produced effects. Recent findings have highlighted the importance of α1 containing GABAA receptors in the mechanisms of addiction and tolerance in benzodiazepine treatments. This has shown promise in the development of tranquilizers with minimal side effects such as cognitive impairment, dependence, and tolerance. A valium-like drug without its side effects, as repeatedly demonstrated in animals, is achievable. Keywords: benzodiazepines, subtype, tolerance, dependence, anxiolytic, GABAA receptorCheng TWallace DMPonteri BTuli MDove Medical PressarticleBenzodiazepinesSubtypeToleranceDependenceAnxiolyticGABAA receptorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1351-1361 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Benzodiazepines Subtype Tolerance Dependence Anxiolytic GABAA receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Benzodiazepines Subtype Tolerance Dependence Anxiolytic GABAA receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Cheng T Wallace DM Ponteri B Tuli M Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
description	Tianze Cheng,1 Dominique Marie Wallace,2 Benjamin Ponteri,1 Mahir Tuli3 1Pitzer College, Claremont, CA, USA; 2Portland State University, Portland, OR, USA; 3University of British Columbia, Vancouver, BC, Canada Abstract: Benzodiazepines are one of the most prescribed medications as first-line treatment of anxiety, insomnia, and epilepsy around the world. Over the past two decades, advances in the neuropharmacological understanding of gamma aminobutyric acid (GABA)A receptors revealed distinct contributions from each subtype and produced effects. Recent findings have highlighted the importance of α1 containing GABAA receptors in the mechanisms of addiction and tolerance in benzodiazepine treatments. This has shown promise in the development of tranquilizers with minimal side effects such as cognitive impairment, dependence, and tolerance. A valium-like drug without its side effects, as repeatedly demonstrated in animals, is achievable. Keywords: benzodiazepines, subtype, tolerance, dependence, anxiolytic, GABAA receptor
format	article
author	Cheng T Wallace DM Ponteri B Tuli M
author_facet	Cheng T Wallace DM Ponteri B Tuli M
author_sort	Cheng T
title	Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
title_short	Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
title_full	Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
title_fullStr	Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
title_full_unstemmed	Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
title_sort	valium without dependence? individual gabaa receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/91bd194a589f4a8490c8b2d796931f6f
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Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects

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