Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.

ERRα is an orphan member of the nuclear receptor family, the complete inactivation of which confers resistance to bone loss induced by ageing and estrogen withdrawal to female mice in correlation with increased bone formation in vivo. Furthermore ERRα negatively regulates the commitment of mesenchym...

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Autores principales: Marlène Gallet, Soraya Saïdi, Eric Haÿ, Johann Photsavang, Caroline Marty, Juliette Sailland, Julie Carnesecchi, Violaine Tribollet, Bruno Barenton, Christelle Forcet, Marie-Christine Birling, Tania Sorg, Olivier Chassande, Martine Cohen-Solal, Jean-Marc Vanacker
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/91c030da2f044faf9fc31ea0ad903484
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spelling oai:doaj.org-article:91c030da2f044faf9fc31ea0ad9034842021-11-18T08:00:11ZRepression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.1932-620310.1371/journal.pone.0054837https://doaj.org/article/91c030da2f044faf9fc31ea0ad9034842013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23359549/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203ERRα is an orphan member of the nuclear receptor family, the complete inactivation of which confers resistance to bone loss induced by ageing and estrogen withdrawal to female mice in correlation with increased bone formation in vivo. Furthermore ERRα negatively regulates the commitment of mesenchymal cells to the osteoblast lineage ex vivo as well as later steps of osteoblast maturation. We searched to determine whether the activities of ERRα on osteoblast maturation are responsible for one or both types of in vivo induced bone loss. To this end we have generated conditional knock out mice in which the receptor is normally present during early osteoblast differentiation but inactivated upon osteoblast maturation. Bone ageing in these animals was similar to that observed for control animals. In contrast conditional ERRαKO mice were completely resistant to bone loss induced by ovariectomy. We conclude that the late (maturation), but not early (commitment), negative effects of ERRα on the osteoblast lineage contribute to the reduced bone mineral density observed upon estrogen deficiency.Marlène GalletSoraya SaïdiEric HaÿJohann PhotsavangCaroline MartyJuliette SaillandJulie CarnesecchiViolaine TribolletBruno BarentonChristelle ForcetMarie-Christine BirlingTania SorgOlivier ChassandeMartine Cohen-SolalJean-Marc VanackerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54837 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Marlène Gallet
Soraya Saïdi
Eric Haÿ
Johann Photsavang
Caroline Marty
Juliette Sailland
Julie Carnesecchi
Violaine Tribollet
Bruno Barenton
Christelle Forcet
Marie-Christine Birling
Tania Sorg
Olivier Chassande
Martine Cohen-Solal
Jean-Marc Vanacker
Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.
description ERRα is an orphan member of the nuclear receptor family, the complete inactivation of which confers resistance to bone loss induced by ageing and estrogen withdrawal to female mice in correlation with increased bone formation in vivo. Furthermore ERRα negatively regulates the commitment of mesenchymal cells to the osteoblast lineage ex vivo as well as later steps of osteoblast maturation. We searched to determine whether the activities of ERRα on osteoblast maturation are responsible for one or both types of in vivo induced bone loss. To this end we have generated conditional knock out mice in which the receptor is normally present during early osteoblast differentiation but inactivated upon osteoblast maturation. Bone ageing in these animals was similar to that observed for control animals. In contrast conditional ERRαKO mice were completely resistant to bone loss induced by ovariectomy. We conclude that the late (maturation), but not early (commitment), negative effects of ERRα on the osteoblast lineage contribute to the reduced bone mineral density observed upon estrogen deficiency.
format article
author Marlène Gallet
Soraya Saïdi
Eric Haÿ
Johann Photsavang
Caroline Marty
Juliette Sailland
Julie Carnesecchi
Violaine Tribollet
Bruno Barenton
Christelle Forcet
Marie-Christine Birling
Tania Sorg
Olivier Chassande
Martine Cohen-Solal
Jean-Marc Vanacker
author_facet Marlène Gallet
Soraya Saïdi
Eric Haÿ
Johann Photsavang
Caroline Marty
Juliette Sailland
Julie Carnesecchi
Violaine Tribollet
Bruno Barenton
Christelle Forcet
Marie-Christine Birling
Tania Sorg
Olivier Chassande
Martine Cohen-Solal
Jean-Marc Vanacker
author_sort Marlène Gallet
title Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.
title_short Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.
title_full Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.
title_fullStr Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.
title_full_unstemmed Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.
title_sort repression of osteoblast maturation by errα accounts for bone loss induced by estrogen deficiency.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/91c030da2f044faf9fc31ea0ad903484
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