Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.

Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.

ERRα is an orphan member of the nuclear receptor family, the complete inactivation of which confers resistance to bone loss induced by ageing and estrogen withdrawal to female mice in correlation with increased bone formation in vivo. Furthermore ERRα negatively regulates the commitment of mesenchym...

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Main Authors: Marlène Gallet, Soraya Saïdi, Eric Haÿ, Johann Photsavang, Caroline Marty, Juliette Sailland, Julie Carnesecchi, Violaine Tribollet, Bruno Barenton, Christelle Forcet, Marie-Christine Birling, Tania Sorg, Olivier Chassande, Martine Cohen-Solal, Jean-Marc Vanacker
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/91c030da2f044faf9fc31ea0ad903484
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