Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study

Abstract Peculiar cognitive profile of patients with SBMA has been described by fragmented literature. Our retrospective study reports the neuropsychological evaluations of a large cohort of patients in order to contribute towards the understanding of this field. We consider 64 neuropsychological ev...

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Autores principales:	S. Marcato, J. R. Kleinbub, G. Querin, E. Pick, I. Martinelli, C. Bertolin, S. Cipolletta, E. Pegoraro, G. Sorarù, A. Palmieri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Spinal And Bulbar Muscular Atrophy (SBMA) Forward Digit Span Prose Memory SBMA Patients Phonemic Fluency Test Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91c0baaf45c142e0a3f7533d9691fedd
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spelling	oai:doaj.org-article:91c0baaf45c142e0a3f7533d9691fedd2021-12-02T15:07:43ZUnimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study10.1038/s41598-018-32062-52045-2322https://doaj.org/article/91c0baaf45c142e0a3f7533d9691fedd2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32062-5https://doaj.org/toc/2045-2322Abstract Peculiar cognitive profile of patients with SBMA has been described by fragmented literature. Our retrospective study reports the neuropsychological evaluations of a large cohort of patients in order to contribute towards the understanding of this field. We consider 64 neuropsychological evaluations assessing mnesic, linguistic and executive functions collected from 2013 to 2015 in patients attending at Motor Neuron Disease Centre of University of Padova. The battery consisted in: Digit Span forwards and backwards, Prose Memory test, Phonemic Verbal fluency and Trail making tests. ANCOVA statistics were employed to compare tests scores results with those obtained from a sample of healthy control subjects. Multiple linear regressions were used to study the effect on cognitive performance of CAG-repeat expansion, the degree of androgen insensitivity and their interaction to cognitive performance. Statistical analyses did not reveal altered scores in any neuropsychological tests among those adopted. Interestingly, patients performed significantly better in the Prose Memory test’s score. No relevant associations were found with genetic, hormonal or clinical patients’ profile. Results inconsistent with previous studies have been interpreted according to the phenomenon of somatic mosaicism. We suggest a testosterone-related and the mood state-dependant perspectives as two possible interpretations of the enhanced performances in the Prose Memory test. Further studies employing more datailed tests batteries are encouraged.S. MarcatoJ. R. KleinbubG. QuerinE. PickI. MartinelliC. BertolinS. CipollettaE. PegoraroG. SorarùA. PalmieriNature PortfolioarticleSpinal And Bulbar Muscular Atrophy (SBMA)Forward Digit SpanProse MemorySBMA PatientsPhonemic Fluency TestMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spinal And Bulbar Muscular Atrophy (SBMA) Forward Digit Span Prose Memory SBMA Patients Phonemic Fluency Test Medicine R Science Q
spellingShingle	Spinal And Bulbar Muscular Atrophy (SBMA) Forward Digit Span Prose Memory SBMA Patients Phonemic Fluency Test Medicine R Science Q S. Marcato J. R. Kleinbub G. Querin E. Pick I. Martinelli C. Bertolin S. Cipolletta E. Pegoraro G. Sorarù A. Palmieri Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study
description	Abstract Peculiar cognitive profile of patients with SBMA has been described by fragmented literature. Our retrospective study reports the neuropsychological evaluations of a large cohort of patients in order to contribute towards the understanding of this field. We consider 64 neuropsychological evaluations assessing mnesic, linguistic and executive functions collected from 2013 to 2015 in patients attending at Motor Neuron Disease Centre of University of Padova. The battery consisted in: Digit Span forwards and backwards, Prose Memory test, Phonemic Verbal fluency and Trail making tests. ANCOVA statistics were employed to compare tests scores results with those obtained from a sample of healthy control subjects. Multiple linear regressions were used to study the effect on cognitive performance of CAG-repeat expansion, the degree of androgen insensitivity and their interaction to cognitive performance. Statistical analyses did not reveal altered scores in any neuropsychological tests among those adopted. Interestingly, patients performed significantly better in the Prose Memory test’s score. No relevant associations were found with genetic, hormonal or clinical patients’ profile. Results inconsistent with previous studies have been interpreted according to the phenomenon of somatic mosaicism. We suggest a testosterone-related and the mood state-dependant perspectives as two possible interpretations of the enhanced performances in the Prose Memory test. Further studies employing more datailed tests batteries are encouraged.
format	article
author	S. Marcato J. R. Kleinbub G. Querin E. Pick I. Martinelli C. Bertolin S. Cipolletta E. Pegoraro G. Sorarù A. Palmieri
author_facet	S. Marcato J. R. Kleinbub G. Querin E. Pick I. Martinelli C. Bertolin S. Cipolletta E. Pegoraro G. Sorarù A. Palmieri
author_sort	S. Marcato
title	Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study
title_short	Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study
title_full	Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study
title_fullStr	Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study
title_full_unstemmed	Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study
title_sort	unimpaired neuropsychological performance and enhanced memory recall in patients with sbma: a large sample comparative study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/91c0baaf45c142e0a3f7533d9691fedd
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Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study

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