A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae

Summary: Cholera is a severe diarrheal disease that places a significant burden on global health. Cholera’s high morbidity demands effective prophylactic strategies, but oral cholera vaccines exhibit variable efficacy in human populations. One contributor of variance in human populations is the gut...

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Autores principales:	John C. Macbeth, Rui Liu, Salma Alavi, Ansel Hsiao
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Disease Microbiology Microbiome Science Q
Acceso en línea:	https://doaj.org/article/91c54b7e8b1740678f9cef2fc39ea2b5
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spelling	oai:doaj.org-article:91c54b7e8b1740678f9cef2fc39ea2b52021-11-28T04:36:28ZA dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae2589-004210.1016/j.isci.2021.103443https://doaj.org/article/91c54b7e8b1740678f9cef2fc39ea2b52021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014140https://doaj.org/toc/2589-0042Summary: Cholera is a severe diarrheal disease that places a significant burden on global health. Cholera’s high morbidity demands effective prophylactic strategies, but oral cholera vaccines exhibit variable efficacy in human populations. One contributor of variance in human populations is the gut microbiome, which in cholera-endemic areas is modulated by malnutrition, cholera, and non-cholera diarrhea. We conducted fecal transplants from healthy human donors and model communities of either human gut microbes that resemble healthy individuals or those of individuals recovering from diarrhea in various mouse models. We show microbiome-specific effects on host antibody responses against Vibrio cholerae, and that dysbiotic human gut microbiomes representative of cholera-endemic areas suppress the immune response against V. cholerae via CD4+ lymphocytes. Our findings suggest that gut microbiome composition at time of infection or vaccination may be pivotal for providing robust mucosal immunity, and suggest a target for improved prophylactic and therapeutic strategies for cholera.John C. MacbethRui LiuSalma AlaviAnsel HsiaoElsevierarticleDiseaseMicrobiologyMicrobiomeScienceQENiScience, Vol 24, Iss 12, Pp 103443- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Disease Microbiology Microbiome Science Q
spellingShingle	Disease Microbiology Microbiome Science Q John C. Macbeth Rui Liu Salma Alavi Ansel Hsiao A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
description	Summary: Cholera is a severe diarrheal disease that places a significant burden on global health. Cholera’s high morbidity demands effective prophylactic strategies, but oral cholera vaccines exhibit variable efficacy in human populations. One contributor of variance in human populations is the gut microbiome, which in cholera-endemic areas is modulated by malnutrition, cholera, and non-cholera diarrhea. We conducted fecal transplants from healthy human donors and model communities of either human gut microbes that resemble healthy individuals or those of individuals recovering from diarrhea in various mouse models. We show microbiome-specific effects on host antibody responses against Vibrio cholerae, and that dysbiotic human gut microbiomes representative of cholera-endemic areas suppress the immune response against V. cholerae via CD4+ lymphocytes. Our findings suggest that gut microbiome composition at time of infection or vaccination may be pivotal for providing robust mucosal immunity, and suggest a target for improved prophylactic and therapeutic strategies for cholera.
format	article
author	John C. Macbeth Rui Liu Salma Alavi Ansel Hsiao
author_facet	John C. Macbeth Rui Liu Salma Alavi Ansel Hsiao
author_sort	John C. Macbeth
title	A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
title_short	A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
title_full	A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
title_fullStr	A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
title_full_unstemmed	A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
title_sort	dysbiotic gut microbiome suppresses antibody mediated-protection against vibrio cholerae
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/91c54b7e8b1740678f9cef2fc39ea2b5
work_keys_str_mv	AT johncmacbeth adysbioticgutmicrobiomesuppressesantibodymediatedprotectionagainstvibriocholerae AT ruiliu adysbioticgutmicrobiomesuppressesantibodymediatedprotectionagainstvibriocholerae AT salmaalavi adysbioticgutmicrobiomesuppressesantibodymediatedprotectionagainstvibriocholerae AT anselhsiao adysbioticgutmicrobiomesuppressesantibodymediatedprotectionagainstvibriocholerae AT johncmacbeth dysbioticgutmicrobiomesuppressesantibodymediatedprotectionagainstvibriocholerae AT ruiliu dysbioticgutmicrobiomesuppressesantibodymediatedprotectionagainstvibriocholerae AT salmaalavi dysbioticgutmicrobiomesuppressesantibodymediatedprotectionagainstvibriocholerae AT anselhsiao dysbioticgutmicrobiomesuppressesantibodymediatedprotectionagainstvibriocholerae
_version_	1718408273131995136

A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae

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