CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies

Nobutaka Hanagata1,2 1Nanotechnology Innovation Station, National Institute for Materials Science, Tsukuba, Ibaraki, 2Graduate School of Life Science, Hokkaido University, Sapporo, Hokkaido, Japan Abstract: Unmethylated cytosine-guanine dinucleotide-containing oligodeoxynucleotides (CpG ODNs), which...

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Autor principal:	Hanagata N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	CpG oligodeoxynucleotides Toll-like receptor 9 immunostimulation nanomedicine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/91c8a9dd1b704c99a1bb001f036d8585
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spelling	oai:doaj.org-article:91c8a9dd1b704c99a1bb001f036d85852021-12-02T02:37:30ZCpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies1178-2013https://doaj.org/article/91c8a9dd1b704c99a1bb001f036d85852017-01-01T00:00:00Zhttps://www.dovepress.com/cpg-oligodeoxynucleotide-nanomedicines-for-the-prophylaxis-or-treatmen-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nobutaka Hanagata1,2 1Nanotechnology Innovation Station, National Institute for Materials Science, Tsukuba, Ibaraki, 2Graduate School of Life Science, Hokkaido University, Sapporo, Hokkaido, Japan Abstract: Unmethylated cytosine-guanine dinucleotide-containing oligodeoxynucleotides (CpG ODNs), which are synthetic agonists of Toll-like receptor 9 (TLR9), activate humoral and cellular immunity and are being developed as vaccine adjuvants to prevent or treat cancers, infectious diseases, and allergies. Free CpG ODNs have been used in many clinical trials implemented to verify their effects. However, recent research has reported that self-assembled CpG ODNs, protein/peptide–CpG ODN conjugates, and nanomaterial–CpG ODN complexes demonstrate higher adjuvant effects than free CpG ODNs, owing to their improved uptake efficiency into cells expressing TLR9. Moreover, protein/peptide–CpG ODN conjugates and nanomaterial–CpG ODN complexes are able to deliver CpG ODNs and antigens (or allergens) to the same types of cells, which enables a higher degree of prophylaxis or therapeutic effect. In this review, the author describes recent trends in the research and development of CpG ODN nanomedicines containing self-assembled CpG ODNs, protein/peptide–CpG ODN conjugates, and nanomaterial–CpG ODN complexes, focusing mainly on the results of preclinical and clinical studies. Keywords: CpG oligodeoxynucleotides, Toll-like receptor 9, immunostimulation, nanomedicine, adjuvantHanagata NDove Medical PressarticleCpG oligodeoxynucleotidesToll-like receptor 9immunostimulationnanomedicineMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 515-531 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	CpG oligodeoxynucleotides Toll-like receptor 9 immunostimulation nanomedicine Medicine (General) R5-920
spellingShingle	CpG oligodeoxynucleotides Toll-like receptor 9 immunostimulation nanomedicine Medicine (General) R5-920 Hanagata N CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
description	Nobutaka Hanagata1,2 1Nanotechnology Innovation Station, National Institute for Materials Science, Tsukuba, Ibaraki, 2Graduate School of Life Science, Hokkaido University, Sapporo, Hokkaido, Japan Abstract: Unmethylated cytosine-guanine dinucleotide-containing oligodeoxynucleotides (CpG ODNs), which are synthetic agonists of Toll-like receptor 9 (TLR9), activate humoral and cellular immunity and are being developed as vaccine adjuvants to prevent or treat cancers, infectious diseases, and allergies. Free CpG ODNs have been used in many clinical trials implemented to verify their effects. However, recent research has reported that self-assembled CpG ODNs, protein/peptide–CpG ODN conjugates, and nanomaterial–CpG ODN complexes demonstrate higher adjuvant effects than free CpG ODNs, owing to their improved uptake efficiency into cells expressing TLR9. Moreover, protein/peptide–CpG ODN conjugates and nanomaterial–CpG ODN complexes are able to deliver CpG ODNs and antigens (or allergens) to the same types of cells, which enables a higher degree of prophylaxis or therapeutic effect. In this review, the author describes recent trends in the research and development of CpG ODN nanomedicines containing self-assembled CpG ODNs, protein/peptide–CpG ODN conjugates, and nanomaterial–CpG ODN complexes, focusing mainly on the results of preclinical and clinical studies. Keywords: CpG oligodeoxynucleotides, Toll-like receptor 9, immunostimulation, nanomedicine, adjuvant
format	article
author	Hanagata N
author_facet	Hanagata N
author_sort	Hanagata N
title	CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
title_short	CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
title_full	CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
title_fullStr	CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
title_full_unstemmed	CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
title_sort	cpg oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/91c8a9dd1b704c99a1bb001f036d8585
work_keys_str_mv	AT hanagatan cpgoligodeoxynucleotidenanomedicinesfortheprophylaxisortreatmentofcancersinfectiousdiseasesandallergies
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CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies

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