Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging
Abstract In hypertrophic cardiomyopathy (HCM) patients, left ventricular (LV) maximal wall thickness (MWT) is one of the most important factors determining sudden cardiac death (SCD) risk. In a large unselected sample of HCM patients, we aimed to simulate what changes would occur in the calculated S...
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Nature Portfolio
2021
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oai:doaj.org-article:91c91190de6c42d0998e13ec42238e2c2021-12-02T14:23:23ZSudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging10.1038/s41598-021-86532-42045-2322https://doaj.org/article/91c91190de6c42d0998e13ec42238e2c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86532-4https://doaj.org/toc/2045-2322Abstract In hypertrophic cardiomyopathy (HCM) patients, left ventricular (LV) maximal wall thickness (MWT) is one of the most important factors determining sudden cardiac death (SCD) risk. In a large unselected sample of HCM patients, we aimed to simulate what changes would occur in the calculated SCD risk according to the European HCM Risk-SCD calculator when MWT measured using echocardiography was changed to MWT measured using MRI. All consecutive patients with HCM who underwent cardiac MRI were included. MWT measured with echocardiography and MRI were compared, and 5-year SCD risk according to the HCM Risk-SCD calculator was computed using four different models. The final population included 673 patients [389 (57.8%) males, median age 50 years, interquartile range (36–60)]. The median MWT was lower measured by echocardiography than by MRI [20 (17–24) mm vs 21 (18–24) mm; p < 0.0001]. There was agreement between echocardiography and MRI in the measurement of maximal LV wall thickness in 96 patients (14.3%). The largest differences between echo and MRI were − 13 mm and + 9 mm. The differences in MWT by echocardiography and MRI translated to a maximal difference of 8.33% in the absolute 5-year risk of SCD, i.e., the echocardiography-based risk was 8.33% lower than the MRI-based estimates. Interestingly, 13.7% of patients would have been reclassified into different SCD risk categories if MRI had been used to measure MWT instead of echocardiography. In conclusion, although there was high general intermodality agreement between echocardiography and MRI in the MWT measurements, the differences in MWT translated to significant differences in the 5-year risk of SCD.Mateusz ŚpiewakMariusz KłopotowskiEwa KowalikAgata KubikNatalia Ojrzyńska-WitekJoanna Petryka-MazurkiewiczEwa MichalakŁukasz MazurkiewiczMonika GaworKatarzyna KożuchBarbara Miłosz-WieczorekJacek GrzybowskiZofia BilińskaAdam WitkowskiAnna KlisiewiczMagdalena MarczakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Mateusz Śpiewak Mariusz Kłopotowski Ewa Kowalik Agata Kubik Natalia Ojrzyńska-Witek Joanna Petryka-Mazurkiewicz Ewa Michalak Łukasz Mazurkiewicz Monika Gawor Katarzyna Kożuch Barbara Miłosz-Wieczorek Jacek Grzybowski Zofia Bilińska Adam Witkowski Anna Klisiewicz Magdalena Marczak Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging |
| description |
Abstract In hypertrophic cardiomyopathy (HCM) patients, left ventricular (LV) maximal wall thickness (MWT) is one of the most important factors determining sudden cardiac death (SCD) risk. In a large unselected sample of HCM patients, we aimed to simulate what changes would occur in the calculated SCD risk according to the European HCM Risk-SCD calculator when MWT measured using echocardiography was changed to MWT measured using MRI. All consecutive patients with HCM who underwent cardiac MRI were included. MWT measured with echocardiography and MRI were compared, and 5-year SCD risk according to the HCM Risk-SCD calculator was computed using four different models. The final population included 673 patients [389 (57.8%) males, median age 50 years, interquartile range (36–60)]. The median MWT was lower measured by echocardiography than by MRI [20 (17–24) mm vs 21 (18–24) mm; p < 0.0001]. There was agreement between echocardiography and MRI in the measurement of maximal LV wall thickness in 96 patients (14.3%). The largest differences between echo and MRI were − 13 mm and + 9 mm. The differences in MWT by echocardiography and MRI translated to a maximal difference of 8.33% in the absolute 5-year risk of SCD, i.e., the echocardiography-based risk was 8.33% lower than the MRI-based estimates. Interestingly, 13.7% of patients would have been reclassified into different SCD risk categories if MRI had been used to measure MWT instead of echocardiography. In conclusion, although there was high general intermodality agreement between echocardiography and MRI in the MWT measurements, the differences in MWT translated to significant differences in the 5-year risk of SCD. |
| format |
article |
| author |
Mateusz Śpiewak Mariusz Kłopotowski Ewa Kowalik Agata Kubik Natalia Ojrzyńska-Witek Joanna Petryka-Mazurkiewicz Ewa Michalak Łukasz Mazurkiewicz Monika Gawor Katarzyna Kożuch Barbara Miłosz-Wieczorek Jacek Grzybowski Zofia Bilińska Adam Witkowski Anna Klisiewicz Magdalena Marczak |
| author_facet |
Mateusz Śpiewak Mariusz Kłopotowski Ewa Kowalik Agata Kubik Natalia Ojrzyńska-Witek Joanna Petryka-Mazurkiewicz Ewa Michalak Łukasz Mazurkiewicz Monika Gawor Katarzyna Kożuch Barbara Miłosz-Wieczorek Jacek Grzybowski Zofia Bilińska Adam Witkowski Anna Klisiewicz Magdalena Marczak |
| author_sort |
Mateusz Śpiewak |
| title |
Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging |
| title_short |
Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging |
| title_full |
Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging |
| title_fullStr |
Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging |
| title_full_unstemmed |
Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging |
| title_sort |
sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/91c91190de6c42d0998e13ec42238e2c |
| work_keys_str_mv |
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