Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding.

Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding.

Hypoxia-Inducible Factor (HIF) transcription factors are heterodimeric proteins involved in the regulation of oxygen homeostatis. Their upregulation has been related to several tumors with a remarkably poor clinical outcome. The recent discovery of a druggable cavity in the HIF-2α PAS-B domain has o...

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Autores principales: Matteo Masetti, Federico Falchi, Maurizio Recanatini
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/91c95918eb064d58a42fd8e7c301d88c
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