Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
BCL2-inhibitor venetoclax is used to treat relapsed/refractory chronic lymphocytic leukemia (CLL). Here, the authors show the clonal dynamics towards venetoclax resistance by performing whole-exome sequencing of 8 CLL patients undergoing venetoclax treatment.
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2018
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oai:doaj.org-article:91cad87502c5439c87643a607b72a3782021-12-02T16:49:31ZClonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia10.1038/s41467-018-03170-72041-1723https://doaj.org/article/91cad87502c5439c87643a607b72a3782018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03170-7https://doaj.org/toc/2041-1723BCL2-inhibitor venetoclax is used to treat relapsed/refractory chronic lymphocytic leukemia (CLL). Here, the authors show the clonal dynamics towards venetoclax resistance by performing whole-exome sequencing of 8 CLL patients undergoing venetoclax treatment.Carmen D. HerlingNima AbedpourJonathan WeissAnna SchmittRon Daniel JachimowiczOlaf MerkelMaria CartolanoSebastian OberbeckPetra MayerValeska BergDaniel ThomallaNadine KutschMarius StiefelhagenPaula CramerClemens-Martin WendtnerThorsten PersigehlAndreas SalehJanine AltmüllerPeter NürnbergChristian PallaschViktor AchterUlrich LangBarbara EichhorstRoberta CastiglioneStephan C. SchäferReinhard BüttnerKarl-Anton KreuzerHans Christian ReinhardtMichael HallekLukas P. FrenzelMartin PeiferNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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EN |
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Science Q |
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Science Q Carmen D. Herling Nima Abedpour Jonathan Weiss Anna Schmitt Ron Daniel Jachimowicz Olaf Merkel Maria Cartolano Sebastian Oberbeck Petra Mayer Valeska Berg Daniel Thomalla Nadine Kutsch Marius Stiefelhagen Paula Cramer Clemens-Martin Wendtner Thorsten Persigehl Andreas Saleh Janine Altmüller Peter Nürnberg Christian Pallasch Viktor Achter Ulrich Lang Barbara Eichhorst Roberta Castiglione Stephan C. Schäfer Reinhard Büttner Karl-Anton Kreuzer Hans Christian Reinhardt Michael Hallek Lukas P. Frenzel Martin Peifer Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia |
| description |
BCL2-inhibitor venetoclax is used to treat relapsed/refractory chronic lymphocytic leukemia (CLL). Here, the authors show the clonal dynamics towards venetoclax resistance by performing whole-exome sequencing of 8 CLL patients undergoing venetoclax treatment. |
| format |
article |
| author |
Carmen D. Herling Nima Abedpour Jonathan Weiss Anna Schmitt Ron Daniel Jachimowicz Olaf Merkel Maria Cartolano Sebastian Oberbeck Petra Mayer Valeska Berg Daniel Thomalla Nadine Kutsch Marius Stiefelhagen Paula Cramer Clemens-Martin Wendtner Thorsten Persigehl Andreas Saleh Janine Altmüller Peter Nürnberg Christian Pallasch Viktor Achter Ulrich Lang Barbara Eichhorst Roberta Castiglione Stephan C. Schäfer Reinhard Büttner Karl-Anton Kreuzer Hans Christian Reinhardt Michael Hallek Lukas P. Frenzel Martin Peifer |
| author_facet |
Carmen D. Herling Nima Abedpour Jonathan Weiss Anna Schmitt Ron Daniel Jachimowicz Olaf Merkel Maria Cartolano Sebastian Oberbeck Petra Mayer Valeska Berg Daniel Thomalla Nadine Kutsch Marius Stiefelhagen Paula Cramer Clemens-Martin Wendtner Thorsten Persigehl Andreas Saleh Janine Altmüller Peter Nürnberg Christian Pallasch Viktor Achter Ulrich Lang Barbara Eichhorst Roberta Castiglione Stephan C. Schäfer Reinhard Büttner Karl-Anton Kreuzer Hans Christian Reinhardt Michael Hallek Lukas P. Frenzel Martin Peifer |
| author_sort |
Carmen D. Herling |
| title |
Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia |
| title_short |
Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia |
| title_full |
Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia |
| title_fullStr |
Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia |
| title_full_unstemmed |
Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia |
| title_sort |
clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/91cad87502c5439c87643a607b72a378 |
| work_keys_str_mv |
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