Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants

Abstract Current pain classifications use 1.0-kg palpation of the masseter muscle to distinguish between “pain patients” and “healthy controls” but a thorough understanding of the normal physiological responses to various somatosensory stimuli is lacking. The aim of this study was to investigate som...

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Autores principales:	Hidetoshi Hayakawa, Takashi Iida, Mika Honda-Sakaki, Manabu Masuda, Peter Svensson, Osamu Komiyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91ccbd6eb0154ca6baa0077e252d5e99
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spelling	oai:doaj.org-article:91ccbd6eb0154ca6baa0077e252d5e992021-12-02T14:59:09ZDrop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants10.1038/s41598-021-89937-32045-2322https://doaj.org/article/91ccbd6eb0154ca6baa0077e252d5e992021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89937-3https://doaj.org/toc/2045-2322Abstract Current pain classifications use 1.0-kg palpation of the masseter muscle to distinguish between “pain patients” and “healthy controls” but a thorough understanding of the normal physiological responses to various somatosensory stimuli is lacking. The aim of this study was to investigate somatosensory function of the skin over the masseter muscle in healthy participants that were divided into a masseter pain prone group (MPP) (n = 22) and non-MPP group (n = 22), according to the response to a 1.0-kg palpation. Quantitative sensory testing (QST) was performed at the skin above the right masseter muscle (homotopic). In an additional experiment, 13 individuals each from MPP and non-MPP received application of 60% topical lidocaine tape to the skin over the masseter muscle for 30 min. Immediately after, mechanical pain sensitivity (MPS), dynamic mechanical allodynia, and pressure pain threshold were tested. Homotopic MPS was significantly higher and PPTs significantly lower in MPP than in N-MPP (P < 0.05). Strikingly, no other differences in QST outcomes were observed between the groups (P > 0.05). After lidocaine application, no significant differences in homotopic MPS were observed between groups. The presence or absence of acute provoked pain in masseter muscle is exclusively associated with differences in homotopic MPS which is decreased following topical anesthesia.Hidetoshi HayakawaTakashi IidaMika Honda-SakakiManabu MasudaPeter SvenssonOsamu KomiyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hidetoshi Hayakawa Takashi Iida Mika Honda-Sakaki Manabu Masuda Peter Svensson Osamu Komiyama Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants
description	Abstract Current pain classifications use 1.0-kg palpation of the masseter muscle to distinguish between “pain patients” and “healthy controls” but a thorough understanding of the normal physiological responses to various somatosensory stimuli is lacking. The aim of this study was to investigate somatosensory function of the skin over the masseter muscle in healthy participants that were divided into a masseter pain prone group (MPP) (n = 22) and non-MPP group (n = 22), according to the response to a 1.0-kg palpation. Quantitative sensory testing (QST) was performed at the skin above the right masseter muscle (homotopic). In an additional experiment, 13 individuals each from MPP and non-MPP received application of 60% topical lidocaine tape to the skin over the masseter muscle for 30 min. Immediately after, mechanical pain sensitivity (MPS), dynamic mechanical allodynia, and pressure pain threshold were tested. Homotopic MPS was significantly higher and PPTs significantly lower in MPP than in N-MPP (P < 0.05). Strikingly, no other differences in QST outcomes were observed between the groups (P > 0.05). After lidocaine application, no significant differences in homotopic MPS were observed between groups. The presence or absence of acute provoked pain in masseter muscle is exclusively associated with differences in homotopic MPS which is decreased following topical anesthesia.
format	article
author	Hidetoshi Hayakawa Takashi Iida Mika Honda-Sakaki Manabu Masuda Peter Svensson Osamu Komiyama
author_facet	Hidetoshi Hayakawa Takashi Iida Mika Honda-Sakaki Manabu Masuda Peter Svensson Osamu Komiyama
author_sort	Hidetoshi Hayakawa
title	Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants
title_short	Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants
title_full	Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants
title_fullStr	Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants
title_full_unstemmed	Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants
title_sort	drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/91ccbd6eb0154ca6baa0077e252d5e99
work_keys_str_mv	AT hidetoshihayakawa drophomotopiceffectsofmassetermusclepainonsomatosensorysensitivityinhealthyparticipants AT takashiiida drophomotopiceffectsofmassetermusclepainonsomatosensorysensitivityinhealthyparticipants AT mikahondasakaki drophomotopiceffectsofmassetermusclepainonsomatosensorysensitivityinhealthyparticipants AT manabumasuda drophomotopiceffectsofmassetermusclepainonsomatosensorysensitivityinhealthyparticipants AT petersvensson drophomotopiceffectsofmassetermusclepainonsomatosensorysensitivityinhealthyparticipants AT osamukomiyama drophomotopiceffectsofmassetermusclepainonsomatosensorysensitivityinhealthyparticipants
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Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants

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