Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies

Long non coding RNAs (lncRNAs) are non-protein or low-protein coding transcripts that contain more than 200 nucleotides. They representing a large share of the cell's transcriptional output, demonstrate functional attributes viz. tissue-specific expression, determination of cell fate, controlle...

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Autores principales:	Nirjhar Bhattacharyya, Vedansh Pandey, Malini Bhattacharyya, Abhijit Dey
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Non coding rnas Alzheimer's disease Huntington's disease Parkinson's disease Schizophrenia Regulatory Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/91ce3bb776904e07a012256c863dd970
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spelling	oai:doaj.org-article:91ce3bb776904e07a012256c863dd9702021-11-20T04:57:40ZRegulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies1818-087610.1016/j.ajps.2021.02.006https://doaj.org/article/91ce3bb776904e07a012256c863dd9702021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1818087621000313https://doaj.org/toc/1818-0876Long non coding RNAs (lncRNAs) are non-protein or low-protein coding transcripts that contain more than 200 nucleotides. They representing a large share of the cell's transcriptional output, demonstrate functional attributes viz. tissue-specific expression, determination of cell fate, controlled expression, RNA processing and editing, dosage compensation, genomic imprinting, conserved evolutionary traits etc. These long non coding variants are well associated with pathogenicity of various diseases including the neurological disorders like Alzheimer's disease, schizophrenia, Huntington's disease, Parkinson's disease etc. Neurological disorders are widespread and there knowing the underlying mechanisms become crucial. The lncRNAs take part in the pathogenesis by a plethora of mechanisms like decoy, scaffold, mi-RNA sequestrator, histone modifiers and in transcriptional interference. Detailed knowledge of the role of lncRNAs can help to use them further as novel biomarkers for therapeutic aspects. Here, in this review we discuss regulation and functional roles of lncRNAs in eight neurological diseases and psychiatric disorders, and the mechanisms by which they act. With these, we try to establish their roles as potential markers and viable diagnostic tools in these disorders.Nirjhar BhattacharyyaVedansh PandeyMalini BhattacharyyaAbhijit DeyElsevierarticleNon coding rnasAlzheimer's diseaseHuntington's diseaseParkinson's diseaseSchizophreniaRegulatoryTherapeutics. PharmacologyRM1-950ENAsian Journal of Pharmaceutical Sciences, Vol 16, Iss 5, Pp 533-550 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Non coding rnas Alzheimer's disease Huntington's disease Parkinson's disease Schizophrenia Regulatory Therapeutics. Pharmacology RM1-950
spellingShingle	Non coding rnas Alzheimer's disease Huntington's disease Parkinson's disease Schizophrenia Regulatory Therapeutics. Pharmacology RM1-950 Nirjhar Bhattacharyya Vedansh Pandey Malini Bhattacharyya Abhijit Dey Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies
description	Long non coding RNAs (lncRNAs) are non-protein or low-protein coding transcripts that contain more than 200 nucleotides. They representing a large share of the cell's transcriptional output, demonstrate functional attributes viz. tissue-specific expression, determination of cell fate, controlled expression, RNA processing and editing, dosage compensation, genomic imprinting, conserved evolutionary traits etc. These long non coding variants are well associated with pathogenicity of various diseases including the neurological disorders like Alzheimer's disease, schizophrenia, Huntington's disease, Parkinson's disease etc. Neurological disorders are widespread and there knowing the underlying mechanisms become crucial. The lncRNAs take part in the pathogenesis by a plethora of mechanisms like decoy, scaffold, mi-RNA sequestrator, histone modifiers and in transcriptional interference. Detailed knowledge of the role of lncRNAs can help to use them further as novel biomarkers for therapeutic aspects. Here, in this review we discuss regulation and functional roles of lncRNAs in eight neurological diseases and psychiatric disorders, and the mechanisms by which they act. With these, we try to establish their roles as potential markers and viable diagnostic tools in these disorders.
format	article
author	Nirjhar Bhattacharyya Vedansh Pandey Malini Bhattacharyya Abhijit Dey
author_facet	Nirjhar Bhattacharyya Vedansh Pandey Malini Bhattacharyya Abhijit Dey
author_sort	Nirjhar Bhattacharyya
title	Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies
title_short	Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies
title_full	Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies
title_fullStr	Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies
title_full_unstemmed	Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies
title_sort	regulatory role of long non coding rnas (lncrnas) in neurological disorders: from novel biomarkers to promising therapeutic strategies
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/91ce3bb776904e07a012256c863dd970
work_keys_str_mv	AT nirjharbhattacharyya regulatoryroleoflongnoncodingrnaslncrnasinneurologicaldisordersfromnovelbiomarkerstopromisingtherapeuticstrategies AT vedanshpandey regulatoryroleoflongnoncodingrnaslncrnasinneurologicaldisordersfromnovelbiomarkerstopromisingtherapeuticstrategies AT malinibhattacharyya regulatoryroleoflongnoncodingrnaslncrnasinneurologicaldisordersfromnovelbiomarkerstopromisingtherapeuticstrategies AT abhijitdey regulatoryroleoflongnoncodingrnaslncrnasinneurologicaldisordersfromnovelbiomarkerstopromisingtherapeuticstrategies
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Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies

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