Injury-activated glial cells promote wound healing of the adult skin in mice

The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing.

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Autores principales:	Vadims Parfejevs, Julien Debbache, Olga Shakhova, Simon M. Schaefer, Mareen Glausch, Michael Wegner, Ueli Suter, Una Riekstina, Sabine Werner, Lukas Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91d26ea46e384fdb9e27908430c6b644
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spelling	oai:doaj.org-article:91d26ea46e384fdb9e27908430c6b6442021-12-02T15:34:48ZInjury-activated glial cells promote wound healing of the adult skin in mice10.1038/s41467-017-01488-22041-1723https://doaj.org/article/91d26ea46e384fdb9e27908430c6b6442018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01488-2https://doaj.org/toc/2041-1723The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing.Vadims ParfejevsJulien DebbacheOlga ShakhovaSimon M. SchaeferMareen GlauschMichael WegnerUeli SuterUna RiekstinaSabine WernerLukas SommerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vadims Parfejevs Julien Debbache Olga Shakhova Simon M. Schaefer Mareen Glausch Michael Wegner Ueli Suter Una Riekstina Sabine Werner Lukas Sommer Injury-activated glial cells promote wound healing of the adult skin in mice
description	The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing.
format	article
author	Vadims Parfejevs Julien Debbache Olga Shakhova Simon M. Schaefer Mareen Glausch Michael Wegner Ueli Suter Una Riekstina Sabine Werner Lukas Sommer
author_facet	Vadims Parfejevs Julien Debbache Olga Shakhova Simon M. Schaefer Mareen Glausch Michael Wegner Ueli Suter Una Riekstina Sabine Werner Lukas Sommer
author_sort	Vadims Parfejevs
title	Injury-activated glial cells promote wound healing of the adult skin in mice
title_short	Injury-activated glial cells promote wound healing of the adult skin in mice
title_full	Injury-activated glial cells promote wound healing of the adult skin in mice
title_fullStr	Injury-activated glial cells promote wound healing of the adult skin in mice
title_full_unstemmed	Injury-activated glial cells promote wound healing of the adult skin in mice
title_sort	injury-activated glial cells promote wound healing of the adult skin in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/91d26ea46e384fdb9e27908430c6b644
work_keys_str_mv	AT vadimsparfejevs injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT juliendebbache injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT olgashakhova injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT simonmschaefer injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT mareenglausch injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT michaelwegner injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT uelisuter injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT unariekstina injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT sabinewerner injuryactivatedglialcellspromotewoundhealingoftheadultskininmice AT lukassommer injuryactivatedglialcellspromotewoundhealingoftheadultskininmice
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Injury-activated glial cells promote wound healing of the adult skin in mice

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