Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study

Markers of cerebral small vessel disease (CSVD) have previously been associated with age-related cognitive decline. Using longitudinal data of cognitively healthy, older adults (N = 216, mean age at baseline = 70.9 years), we investigated baseline status and change in white matter hyperintensities (...

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Autores principales:	Isabel Hotz, Pascal Frédéric Deschwanden, Susan Mérillat, Franziskus Liem, Spyridon Kollias, Lutz Jäncke
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cerebral small vessel disease White matter hyperintensities Lacunes Brain volumes Processing speed Longitudinal analysis Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/91d3e9b821124a95b4523fb892880219
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spelling	oai:doaj.org-article:91d3e9b821124a95b4523fb8928802192021-11-26T04:28:48ZAssociations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study2213-158210.1016/j.nicl.2021.102884https://doaj.org/article/91d3e9b821124a95b4523fb8928802192021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003284https://doaj.org/toc/2213-1582Markers of cerebral small vessel disease (CSVD) have previously been associated with age-related cognitive decline. Using longitudinal data of cognitively healthy, older adults (N = 216, mean age at baseline = 70.9 years), we investigated baseline status and change in white matter hyperintensities (WMH) (total, periventricular, deep), normal appearing white matter (NAWM), brain parenchyma volume (BPV) and processing speed over seven years as well as the impact of different covariates by applying latent growth curve (LGC) models. Generally, we revealed a complex pattern of associations between the different CSVD markers. More specifically, we observed that changes of deep WMH (dWMH), as compared to periventricular WMH (pWMH), were more strongly related to the changes of other CSVD markers and also to baseline processing speed performance. Further, the number of lacunes rather than their volume reflected the severity of CSVD. With respect to the studied covariates, we revealed that higher education had a protective effect on subsequent total WMH, pWMH, lacunar number, NAWM volume, and processing speed performance. The indication of antihypertensive drugs was associated with lower lacunar number and volume at baseline and the indication of antihypercholesterolemic drugs came along with higher processing speed performance at baseline. In summary, our results confirm previous findings, and extend them by providing information on true within-person changes, relationships between the different CSVD markers and brain-behavior associations. The moderate to strong associations between changes of the different CSVD markers indicate a common pathological relationship and, thus, support multidimensional treatment strategies.Isabel HotzPascal Frédéric DeschwandenSusan MérillatFranziskus LiemSpyridon KolliasLutz JänckeElsevierarticleCerebral small vessel diseaseWhite matter hyperintensitiesLacunesBrain volumesProcessing speedLongitudinal analysisComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102884- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cerebral small vessel disease White matter hyperintensities Lacunes Brain volumes Processing speed Longitudinal analysis Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Cerebral small vessel disease White matter hyperintensities Lacunes Brain volumes Processing speed Longitudinal analysis Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Isabel Hotz Pascal Frédéric Deschwanden Susan Mérillat Franziskus Liem Spyridon Kollias Lutz Jäncke Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study
description	Markers of cerebral small vessel disease (CSVD) have previously been associated with age-related cognitive decline. Using longitudinal data of cognitively healthy, older adults (N = 216, mean age at baseline = 70.9 years), we investigated baseline status and change in white matter hyperintensities (WMH) (total, periventricular, deep), normal appearing white matter (NAWM), brain parenchyma volume (BPV) and processing speed over seven years as well as the impact of different covariates by applying latent growth curve (LGC) models. Generally, we revealed a complex pattern of associations between the different CSVD markers. More specifically, we observed that changes of deep WMH (dWMH), as compared to periventricular WMH (pWMH), were more strongly related to the changes of other CSVD markers and also to baseline processing speed performance. Further, the number of lacunes rather than their volume reflected the severity of CSVD. With respect to the studied covariates, we revealed that higher education had a protective effect on subsequent total WMH, pWMH, lacunar number, NAWM volume, and processing speed performance. The indication of antihypertensive drugs was associated with lower lacunar number and volume at baseline and the indication of antihypercholesterolemic drugs came along with higher processing speed performance at baseline. In summary, our results confirm previous findings, and extend them by providing information on true within-person changes, relationships between the different CSVD markers and brain-behavior associations. The moderate to strong associations between changes of the different CSVD markers indicate a common pathological relationship and, thus, support multidimensional treatment strategies.
format	article
author	Isabel Hotz Pascal Frédéric Deschwanden Susan Mérillat Franziskus Liem Spyridon Kollias Lutz Jäncke
author_facet	Isabel Hotz Pascal Frédéric Deschwanden Susan Mérillat Franziskus Liem Spyridon Kollias Lutz Jäncke
author_sort	Isabel Hotz
title	Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study
title_short	Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study
title_full	Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study
title_fullStr	Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study
title_full_unstemmed	Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study
title_sort	associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: a 7-year study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/91d3e9b821124a95b4523fb892880219
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Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study

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