The role of matrix metalloproteinases in the myocardial remodeling

The main structural event in the development of heart failure is the myocardial remodeling. The extracellular matrix, that was knows as, considered an inert framework of cardiomyocytes, plays an important role in cardiac remodeling. The enzyme system, primarily responsible for the degradation of the...

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Autores principales:	Vladlen V. Bazylev, Tatyana V. Kanaeva
Formato:	article
Lenguaje:	EN RU
Publicado:	Concilium Medicum 2020
Materias:	matrix metalloproteinases myocardial remodeling сhronic heart failure Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/91d5a24df8c440d983c6d01e41358d61
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id	oai:doaj.org-article:91d5a24df8c440d983c6d01e41358d61
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spelling	oai:doaj.org-article:91d5a24df8c440d983c6d01e41358d612021-12-01T22:07:01ZThe role of matrix metalloproteinases in the myocardial remodeling2221-71852658-570710.26442/22217185.2020.3.200374https://doaj.org/article/91d5a24df8c440d983c6d01e41358d612020-11-01T00:00:00Zhttps://cardiosomatics.orscience.ru/2221-7185/article/viewFile/51495/34952https://doaj.org/toc/2221-7185https://doaj.org/toc/2658-5707The main structural event in the development of heart failure is the myocardial remodeling. The extracellular matrix, that was knows as, considered an inert framework of cardiomyocytes, plays an important role in cardiac remodeling. The enzyme system, primarily responsible for the degradation of the extracellular matrix, is a matrix metalloproteinases (MMP). This review examines the evidence for the participation of MMP in the myocardial remodeling and recent studies of MMP as prognostic markers. Regulation of induction and/or activation of MMP are potential therapeutic targets.Vladlen V. BazylevTatyana V. KanaevaConcilium Medicumarticlematrix metalloproteinasesmyocardial remodelingсhronic heart failureDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUКардиоСоматика, Vol 11, Iss 3, Pp 22-28 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	matrix metalloproteinases myocardial remodeling сhronic heart failure Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	matrix metalloproteinases myocardial remodeling сhronic heart failure Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Vladlen V. Bazylev Tatyana V. Kanaeva The role of matrix metalloproteinases in the myocardial remodeling
description	The main structural event in the development of heart failure is the myocardial remodeling. The extracellular matrix, that was knows as, considered an inert framework of cardiomyocytes, plays an important role in cardiac remodeling. The enzyme system, primarily responsible for the degradation of the extracellular matrix, is a matrix metalloproteinases (MMP). This review examines the evidence for the participation of MMP in the myocardial remodeling and recent studies of MMP as prognostic markers. Regulation of induction and/or activation of MMP are potential therapeutic targets.
format	article
author	Vladlen V. Bazylev Tatyana V. Kanaeva
author_facet	Vladlen V. Bazylev Tatyana V. Kanaeva
author_sort	Vladlen V. Bazylev
title	The role of matrix metalloproteinases in the myocardial remodeling
title_short	The role of matrix metalloproteinases in the myocardial remodeling
title_full	The role of matrix metalloproteinases in the myocardial remodeling
title_fullStr	The role of matrix metalloproteinases in the myocardial remodeling
title_full_unstemmed	The role of matrix metalloproteinases in the myocardial remodeling
title_sort	role of matrix metalloproteinases in the myocardial remodeling
publisher	Concilium Medicum
publishDate	2020
url	https://doaj.org/article/91d5a24df8c440d983c6d01e41358d61
work_keys_str_mv	AT vladlenvbazylev theroleofmatrixmetalloproteinasesinthemyocardialremodeling AT tatyanavkanaeva theroleofmatrixmetalloproteinasesinthemyocardialremodeling AT vladlenvbazylev roleofmatrixmetalloproteinasesinthemyocardialremodeling AT tatyanavkanaeva roleofmatrixmetalloproteinasesinthemyocardialremodeling
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The role of matrix metalloproteinases in the myocardial remodeling

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