Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy

Abstract In the present work, we constructed nanoscale graphene oxide (NGO) as a drug nanocarrier to improve the process of tumor-targeted drug releases, promote cellular uptake and accumulation of chemotherapy drugs in tumor tissues, and reduce the toxic effects of chemotherapy drugs on normal cell...

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Autores principales:	Ran Li, Yimei Wang, Jie Du, Xiangyu Wang, Ailin Duan, Ruifang Gao, Junyu Liu, Bing Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91d687fcae1f40e2bbb08d73a1ee3a72
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spelling	oai:doaj.org-article:91d687fcae1f40e2bbb08d73a1ee3a722021-12-02T10:49:30ZGraphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy10.1038/s41598-021-81218-32045-2322https://doaj.org/article/91d687fcae1f40e2bbb08d73a1ee3a722021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81218-3https://doaj.org/toc/2045-2322Abstract In the present work, we constructed nanoscale graphene oxide (NGO) as a drug nanocarrier to improve the process of tumor-targeted drug releases, promote cellular uptake and accumulation of chemotherapy drugs in tumor tissues, and reduce the toxic effects of chemotherapy drugs on normal cells. Hence, great stability was obtained in the biological solution. Moreover, we designed an effective nanoparticle system for the doxorubicin (DOX) delivery targeting the oral squamous cell carcinoma (OSCC) by mediating the HN-1 (TSPLNIHNGQKL) through hydrogen and π–π bonds. DOX@NGO-PEG-HN-1 showed significantly higher cellular uptakes and cytotoxicity in OSCC cells (CAL-27 and SCC-25), compared to free DOX. Moreover, HN-1 showed considerable tumor-targeting and competition inhibition phenomenon. As we expected, the nanocarrier showed pH-responsive drug release. In total, our study represented a good technique to construct OSCC-targeted delivery of nanoparticles and improve the anticancer medicines’ efficiency.Ran LiYimei WangJie DuXiangyu WangAilin DuanRuifang GaoJunyu LiuBing LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ran Li Yimei Wang Jie Du Xiangyu Wang Ailin Duan Ruifang Gao Junyu Liu Bing Li Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
description	Abstract In the present work, we constructed nanoscale graphene oxide (NGO) as a drug nanocarrier to improve the process of tumor-targeted drug releases, promote cellular uptake and accumulation of chemotherapy drugs in tumor tissues, and reduce the toxic effects of chemotherapy drugs on normal cells. Hence, great stability was obtained in the biological solution. Moreover, we designed an effective nanoparticle system for the doxorubicin (DOX) delivery targeting the oral squamous cell carcinoma (OSCC) by mediating the HN-1 (TSPLNIHNGQKL) through hydrogen and π–π bonds. DOX@NGO-PEG-HN-1 showed significantly higher cellular uptakes and cytotoxicity in OSCC cells (CAL-27 and SCC-25), compared to free DOX. Moreover, HN-1 showed considerable tumor-targeting and competition inhibition phenomenon. As we expected, the nanocarrier showed pH-responsive drug release. In total, our study represented a good technique to construct OSCC-targeted delivery of nanoparticles and improve the anticancer medicines’ efficiency.
format	article
author	Ran Li Yimei Wang Jie Du Xiangyu Wang Ailin Duan Ruifang Gao Junyu Liu Bing Li
author_facet	Ran Li Yimei Wang Jie Du Xiangyu Wang Ailin Duan Ruifang Gao Junyu Liu Bing Li
author_sort	Ran Li
title	Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
title_short	Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
title_full	Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
title_fullStr	Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
title_full_unstemmed	Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
title_sort	graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/91d687fcae1f40e2bbb08d73a1ee3a72
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Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy

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