Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases

Abstract Cement augmentation via percutaneous vertebroplasty or kyphoplasty for treatment of spinal metastasis is a well-established treatment option. We assessed whether elevated intrametastatic pressure during cement augmentation results in an increased dissemination of tumour cells into the vascu...

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Autores principales: Malte Mohme, Sabine Riethdorf, Marc Dreimann, Stefan Werner, Cecile L. Maire, Simon A. Joosse, Frederic Bludau, Volkmar Mueller, Rui P. L. Neves, Nikolas H. Stoecklein, Katrin Lamszus, Manfred Westphal, Klaus Pantel, Harriet Wikman, Sven O. Eicker
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Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:91d6cac1f9e843848dfa4e20a239fc072021-12-02T16:07:01ZCirculating Tumour Cell Release after Cement Augmentation of Vertebral Metastases10.1038/s41598-017-07649-z2045-2322https://doaj.org/article/91d6cac1f9e843848dfa4e20a239fc072017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07649-zhttps://doaj.org/toc/2045-2322Abstract Cement augmentation via percutaneous vertebroplasty or kyphoplasty for treatment of spinal metastasis is a well-established treatment option. We assessed whether elevated intrametastatic pressure during cement augmentation results in an increased dissemination of tumour cells into the vascular circulation. We prospectively collected blood from patients with osteolytic spinal column metastases and analysed the prevalence of circulating tumour cells (CTCs) at three time-points: preoperatively, 20 minutes after cement augmentation, and 3–5 days postoperatively. Enrolling 21 patients, including 13 breast- (61.9%), 5 lung- (23.8%), and one (4.8%) colorectal-, renal-, and prostate-carcinoma patient each, we demonstrate a significant 1.8-fold increase of EpCAM+/K+ CTCs in samples taken 20 minutes post-cement augmentation (P < 0.0001). Despite increased mechanical CTC dissemination due to cement augmentation, follow-up blood draws demonstrated that no long-term increase of CTCs was present. Array-CGH analysis revealed a specific profile of the CTC collected 20 minutes after cement augmentation. This is the first study to report that peripheral CTCs are temporarily increased due to vertebral cement augmentation procedures. Our findings provide a rationale for the development of new prophylactic strategies to reduce the increased release of CTC after cement augmentation of osteolytic spinal metastases.Malte MohmeSabine RiethdorfMarc DreimannStefan WernerCecile L. MaireSimon A. JoosseFrederic BludauVolkmar MuellerRui P. L. NevesNikolas H. StoeckleinKatrin LamszusManfred WestphalKlaus PantelHarriet WikmanSven O. EickerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Malte Mohme
Sabine Riethdorf
Marc Dreimann
Stefan Werner
Cecile L. Maire
Simon A. Joosse
Frederic Bludau
Volkmar Mueller
Rui P. L. Neves
Nikolas H. Stoecklein
Katrin Lamszus
Manfred Westphal
Klaus Pantel
Harriet Wikman
Sven O. Eicker
Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
description Abstract Cement augmentation via percutaneous vertebroplasty or kyphoplasty for treatment of spinal metastasis is a well-established treatment option. We assessed whether elevated intrametastatic pressure during cement augmentation results in an increased dissemination of tumour cells into the vascular circulation. We prospectively collected blood from patients with osteolytic spinal column metastases and analysed the prevalence of circulating tumour cells (CTCs) at three time-points: preoperatively, 20 minutes after cement augmentation, and 3–5 days postoperatively. Enrolling 21 patients, including 13 breast- (61.9%), 5 lung- (23.8%), and one (4.8%) colorectal-, renal-, and prostate-carcinoma patient each, we demonstrate a significant 1.8-fold increase of EpCAM+/K+ CTCs in samples taken 20 minutes post-cement augmentation (P < 0.0001). Despite increased mechanical CTC dissemination due to cement augmentation, follow-up blood draws demonstrated that no long-term increase of CTCs was present. Array-CGH analysis revealed a specific profile of the CTC collected 20 minutes after cement augmentation. This is the first study to report that peripheral CTCs are temporarily increased due to vertebral cement augmentation procedures. Our findings provide a rationale for the development of new prophylactic strategies to reduce the increased release of CTC after cement augmentation of osteolytic spinal metastases.
format article
author Malte Mohme
Sabine Riethdorf
Marc Dreimann
Stefan Werner
Cecile L. Maire
Simon A. Joosse
Frederic Bludau
Volkmar Mueller
Rui P. L. Neves
Nikolas H. Stoecklein
Katrin Lamszus
Manfred Westphal
Klaus Pantel
Harriet Wikman
Sven O. Eicker
author_facet Malte Mohme
Sabine Riethdorf
Marc Dreimann
Stefan Werner
Cecile L. Maire
Simon A. Joosse
Frederic Bludau
Volkmar Mueller
Rui P. L. Neves
Nikolas H. Stoecklein
Katrin Lamszus
Manfred Westphal
Klaus Pantel
Harriet Wikman
Sven O. Eicker
author_sort Malte Mohme
title Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
title_short Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
title_full Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
title_fullStr Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
title_full_unstemmed Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
title_sort circulating tumour cell release after cement augmentation of vertebral metastases
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/91d6cac1f9e843848dfa4e20a239fc07
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