A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor
Hang Chen, Xiaoqian Zhao, Zhong Xi, Ye Zhang, Hang Li, Zengyao Li, Haoze Shi, Longchang Huang, Renhui Shen, Jianxin Tao, Tong WangDepartment of General Surgery, Nanjing Medical University Affiliated Wuxi People’s Hospital, Wuxi, Jiangsu Province, People’s Republic of ChinaBackgro...
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Dove Medical Press
2019
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oai:doaj.org-article:91d947405c914741b206e244a55e69ec2021-12-02T00:50:42ZA new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor1178-2013https://doaj.org/article/91d947405c914741b206e244a55e69ec2019-04-01T00:00:00Zhttps://www.dovepress.com/a-new-biosensor-detection-system-to-overcome-the-debye-screening-effec-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hang Chen, Xiaoqian Zhao, Zhong Xi, Ye Zhang, Hang Li, Zengyao Li, Haoze Shi, Longchang Huang, Renhui Shen, Jianxin Tao, Tong WangDepartment of General Surgery, Nanjing Medical University Affiliated Wuxi People’s Hospital, Wuxi, Jiangsu Province, People’s Republic of ChinaBackground: A silicon nanowire field effect transistor biosensor has four advantages in the detection of small biomolecules. It is mark-free, immediately responsive, highly sensitive, and specific. However, because of environments with a high salt concentration, the Debye screening effect has been a major issue in biological detection.Objective: To overcome Debye screening effect, realize the clinical application of silicon nanowire field effect transistor and verify its specificity and sensitivity.Materials and methods: The test solution was desalted by miniature blood dialyzer, and then the tumor markers were detected by silicon nanowire field effect transistor.Results: Tumor markers in serum were detected successfully and their sensitivity and specificity were verified.Conclusion: This method was found to effectively promote the development of semiconductor materials in biological solution detection.Keywords: silicon nanowire, biosensor, Debye screening effect, tumor marker, dialysisChen HZhao XXi ZZhang YLi HLi ZShi HHuang LShen RTao JWang TDove Medical Pressarticlesilicon nanowirebiosensorDebye screening effecttumor markerdialysisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2985-2993 (2019) |
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silicon nanowire biosensor Debye screening effect tumor marker dialysis Medicine (General) R5-920 |
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silicon nanowire biosensor Debye screening effect tumor marker dialysis Medicine (General) R5-920 Chen H Zhao X Xi Z Zhang Y Li H Li Z Shi H Huang L Shen R Tao J Wang T A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor |
| description |
Hang Chen, Xiaoqian Zhao, Zhong Xi, Ye Zhang, Hang Li, Zengyao Li, Haoze Shi, Longchang Huang, Renhui Shen, Jianxin Tao, Tong WangDepartment of General Surgery, Nanjing Medical University Affiliated Wuxi People’s Hospital, Wuxi, Jiangsu Province, People’s Republic of ChinaBackground: A silicon nanowire field effect transistor biosensor has four advantages in the detection of small biomolecules. It is mark-free, immediately responsive, highly sensitive, and specific. However, because of environments with a high salt concentration, the Debye screening effect has been a major issue in biological detection.Objective: To overcome Debye screening effect, realize the clinical application of silicon nanowire field effect transistor and verify its specificity and sensitivity.Materials and methods: The test solution was desalted by miniature blood dialyzer, and then the tumor markers were detected by silicon nanowire field effect transistor.Results: Tumor markers in serum were detected successfully and their sensitivity and specificity were verified.Conclusion: This method was found to effectively promote the development of semiconductor materials in biological solution detection.Keywords: silicon nanowire, biosensor, Debye screening effect, tumor marker, dialysis |
| format |
article |
| author |
Chen H Zhao X Xi Z Zhang Y Li H Li Z Shi H Huang L Shen R Tao J Wang T |
| author_facet |
Chen H Zhao X Xi Z Zhang Y Li H Li Z Shi H Huang L Shen R Tao J Wang T |
| author_sort |
Chen H |
| title |
A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor |
| title_short |
A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor |
| title_full |
A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor |
| title_fullStr |
A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor |
| title_full_unstemmed |
A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor |
| title_sort |
new biosensor detection system to overcome the debye screening effect: dialysis-silicon nanowire field effect transistor |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/91d947405c914741b206e244a55e69ec |
| work_keys_str_mv |
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