Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.

<h4>Background</h4>The mortality burden of the 2009 A/H1N1 pandemic remains unclear in many countries due to delays in reporting of death statistics. We estimate the age- and cause-specific excess mortality impact of the pandemic in France, relative to that of other countries and past ep...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Magali Lemaitre, Fabrice Carrat, Grégoire Rey, Mark Miller, Lone Simonsen, Cécile Viboud
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91dac51f81f24fa39e898438f3cc7e2d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:91dac51f81f24fa39e898438f3cc7e2d
record_format	dspace
spelling	oai:doaj.org-article:91dac51f81f24fa39e898438f3cc7e2d2021-11-18T07:04:48ZMortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.1932-620310.1371/journal.pone.0045051https://doaj.org/article/91dac51f81f24fa39e898438f3cc7e2d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028756/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The mortality burden of the 2009 A/H1N1 pandemic remains unclear in many countries due to delays in reporting of death statistics. We estimate the age- and cause-specific excess mortality impact of the pandemic in France, relative to that of other countries and past epidemic and pandemic seasons.<h4>Methods</h4>We applied Serfling and Poisson excess mortality approaches to model weekly age- and cause-specific mortality rates from June 1969 through May 2010 in France. Indicators of influenza activity, time trends, and seasonal terms were included in the models. We also reviewed the literature for country-specific estimates of 2009 pandemic excess mortality rates to characterize geographical differences in the burden of this pandemic.<h4>Results</h4>The 2009 A/H1N1 pandemic was associated with 1.0 (95% Confidence Intervals (CI) 0.2-1.9) excess respiratory deaths per 100,000 population in France, compared to rates per 100,000 of 44 (95% CI 43-45) for the A/H3N2 pandemic and 2.9 (95% CI 2.3-3.7) for average inter-pandemic seasons. The 2009 A/H1N1 pandemic had a 10.6-fold higher impact than inter-pandemic seasons in people aged 5-24 years and 3.8-fold lower impact among people over 65 years.<h4>Conclusions</h4>The 2009 pandemic in France had low mortality impact in most age groups, relative to past influenza seasons, except in school-age children and young adults. The historical A/H3N2 pandemic was associated with much larger mortality impact than the 2009 pandemic, across all age groups and outcomes. Our 2009 pandemic excess mortality estimates for France fall within the range of previous estimates for high-income regions. Based on the analysis of several mortality outcomes and comparison with laboratory-confirmed 2009/H1N1 deaths, we conclude that cardio-respiratory and all-cause mortality lack precision to accurately measure the impact of this pandemic in high-income settings and that use of more specific mortality outcomes is important to obtain reliable age-specific estimates.Magali LemaitreFabrice CarratGrégoire ReyMark MillerLone SimonsenCécile ViboudPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45051 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Magali Lemaitre Fabrice Carrat Grégoire Rey Mark Miller Lone Simonsen Cécile Viboud Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.
description	<h4>Background</h4>The mortality burden of the 2009 A/H1N1 pandemic remains unclear in many countries due to delays in reporting of death statistics. We estimate the age- and cause-specific excess mortality impact of the pandemic in France, relative to that of other countries and past epidemic and pandemic seasons.<h4>Methods</h4>We applied Serfling and Poisson excess mortality approaches to model weekly age- and cause-specific mortality rates from June 1969 through May 2010 in France. Indicators of influenza activity, time trends, and seasonal terms were included in the models. We also reviewed the literature for country-specific estimates of 2009 pandemic excess mortality rates to characterize geographical differences in the burden of this pandemic.<h4>Results</h4>The 2009 A/H1N1 pandemic was associated with 1.0 (95% Confidence Intervals (CI) 0.2-1.9) excess respiratory deaths per 100,000 population in France, compared to rates per 100,000 of 44 (95% CI 43-45) for the A/H3N2 pandemic and 2.9 (95% CI 2.3-3.7) for average inter-pandemic seasons. The 2009 A/H1N1 pandemic had a 10.6-fold higher impact than inter-pandemic seasons in people aged 5-24 years and 3.8-fold lower impact among people over 65 years.<h4>Conclusions</h4>The 2009 pandemic in France had low mortality impact in most age groups, relative to past influenza seasons, except in school-age children and young adults. The historical A/H3N2 pandemic was associated with much larger mortality impact than the 2009 pandemic, across all age groups and outcomes. Our 2009 pandemic excess mortality estimates for France fall within the range of previous estimates for high-income regions. Based on the analysis of several mortality outcomes and comparison with laboratory-confirmed 2009/H1N1 deaths, we conclude that cardio-respiratory and all-cause mortality lack precision to accurately measure the impact of this pandemic in high-income settings and that use of more specific mortality outcomes is important to obtain reliable age-specific estimates.
format	article
author	Magali Lemaitre Fabrice Carrat Grégoire Rey Mark Miller Lone Simonsen Cécile Viboud
author_facet	Magali Lemaitre Fabrice Carrat Grégoire Rey Mark Miller Lone Simonsen Cécile Viboud
author_sort	Magali Lemaitre
title	Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.
title_short	Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.
title_full	Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.
title_fullStr	Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.
title_full_unstemmed	Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.
title_sort	mortality burden of the 2009 a/h1n1 influenza pandemic in france: comparison to seasonal influenza and the a/h3n2 pandemic.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/91dac51f81f24fa39e898438f3cc7e2d
work_keys_str_mv	AT magalilemaitre mortalityburdenofthe2009ah1n1influenzapandemicinfrancecomparisontoseasonalinfluenzaandtheah3n2pandemic AT fabricecarrat mortalityburdenofthe2009ah1n1influenzapandemicinfrancecomparisontoseasonalinfluenzaandtheah3n2pandemic AT gregoirerey mortalityburdenofthe2009ah1n1influenzapandemicinfrancecomparisontoseasonalinfluenzaandtheah3n2pandemic AT markmiller mortalityburdenofthe2009ah1n1influenzapandemicinfrancecomparisontoseasonalinfluenzaandtheah3n2pandemic AT lonesimonsen mortalityburdenofthe2009ah1n1influenzapandemicinfrancecomparisontoseasonalinfluenzaandtheah3n2pandemic AT cecileviboud mortalityburdenofthe2009ah1n1influenzapandemicinfrancecomparisontoseasonalinfluenzaandtheah3n2pandemic
_version_	1718423992602198016

Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic.

Ejemplares similares