Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel
Abstract The effect of uridine on the myocardial ischemic and reperfusion injury was investigated. A possible mechanism of its cardioprotective action was established. Two rat models were used: (1) acute myocardial ischemia induced by occlusion of the left coronary artery for 60 min; and (2) myocard...
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Main Authors: | Irina B. Krylova, Elena N. Selina, Valentina V. Bulion, Olga M. Rodionova, Natalia R. Evdokimova, Natalia V. Belosludtseva, Maria I. Shigaeva, Galina D. Mironova |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Subjects: | |
Online Access: | https://doaj.org/article/91dce8832b204e19896e31278e998607 |
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