Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting

Abstract Background Sickle cell anaemia (SCA) is the commonest monogenic haematologic disorder resulting from the inheritance of homozygous mutant haemoglobin genes from both parents. Some factors have been identified as important in explaining the variability in depression in sickle cell anaemia (S...

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Autores principales:	Osita Ezenwosu, Barth Chukwu, Ifeyinwa Ezenwosu, Ndubuisi Uwaezuoke, Christopher Eke, Maria Udorah, Chinedu Idoko, Anthony Ikefuna, Ifeoma Emodi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Factors Depression Children Adolescents Sickle cell Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/91dec0e3c0ae4749921196f3e992e468
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spelling	oai:doaj.org-article:91dec0e3c0ae4749921196f3e992e4682021-12-05T12:21:19ZClinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting10.1186/s12887-021-03015-11471-2431https://doaj.org/article/91dec0e3c0ae4749921196f3e992e4682021-12-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-03015-1https://doaj.org/toc/1471-2431Abstract Background Sickle cell anaemia (SCA) is the commonest monogenic haematologic disorder resulting from the inheritance of homozygous mutant haemoglobin genes from both parents. Some factors have been identified as important in explaining the variability in depression in sickle cell anaemia (SCA). Information on this is limited in a resource-limited setting like Nigeria. This study aims to determine factors which influence depression in children and adolescents with sickle cell anaemia in a resource-limited setting. Methods Systematic random sampling technique was used in this cross-sectional study to select children and adolescents aged 7–17 years at the weekly sickle cell clinic of the University of Nigeria Teaching hospital (UNTH) Enugu, Nigeria. Pretested, structured questionnaire was used to collect sociodemographic and disease severity data while depression was assessed using the Children’s Depression Inventory. Results Age and educational level had significant positive linear relationships with depression (r = 0.253, p = 0.02; r = 0.225, p = 0.04 respectively) while gender (χ2 = 0.531, p = 0.466), socioeconomic status (χ2 = 0.451, p = 0.798) and disease severity (χ2 = 0.422, p = 0.810) had no relationship with depression in children and adolescents with SCA. Conclusion Depression in children and adolescents with SCA increased with increasing age and educational level. Psychological evaluation should be integrated into routine assessment of children with SCA during their follow up visits as they get older and progress in class.Osita EzenwosuBarth ChukwuIfeyinwa EzenwosuNdubuisi UwaezuokeChristopher EkeMaria UdorahChinedu IdokoAnthony IkefunaIfeoma EmodiBMCarticleFactorsDepressionChildrenAdolescentsSickle cellPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Factors Depression Children Adolescents Sickle cell Pediatrics RJ1-570
spellingShingle	Factors Depression Children Adolescents Sickle cell Pediatrics RJ1-570 Osita Ezenwosu Barth Chukwu Ifeyinwa Ezenwosu Ndubuisi Uwaezuoke Christopher Eke Maria Udorah Chinedu Idoko Anthony Ikefuna Ifeoma Emodi Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting
description	Abstract Background Sickle cell anaemia (SCA) is the commonest monogenic haematologic disorder resulting from the inheritance of homozygous mutant haemoglobin genes from both parents. Some factors have been identified as important in explaining the variability in depression in sickle cell anaemia (SCA). Information on this is limited in a resource-limited setting like Nigeria. This study aims to determine factors which influence depression in children and adolescents with sickle cell anaemia in a resource-limited setting. Methods Systematic random sampling technique was used in this cross-sectional study to select children and adolescents aged 7–17 years at the weekly sickle cell clinic of the University of Nigeria Teaching hospital (UNTH) Enugu, Nigeria. Pretested, structured questionnaire was used to collect sociodemographic and disease severity data while depression was assessed using the Children’s Depression Inventory. Results Age and educational level had significant positive linear relationships with depression (r = 0.253, p = 0.02; r = 0.225, p = 0.04 respectively) while gender (χ2 = 0.531, p = 0.466), socioeconomic status (χ2 = 0.451, p = 0.798) and disease severity (χ2 = 0.422, p = 0.810) had no relationship with depression in children and adolescents with SCA. Conclusion Depression in children and adolescents with SCA increased with increasing age and educational level. Psychological evaluation should be integrated into routine assessment of children with SCA during their follow up visits as they get older and progress in class.
format	article
author	Osita Ezenwosu Barth Chukwu Ifeyinwa Ezenwosu Ndubuisi Uwaezuoke Christopher Eke Maria Udorah Chinedu Idoko Anthony Ikefuna Ifeoma Emodi
author_facet	Osita Ezenwosu Barth Chukwu Ifeyinwa Ezenwosu Ndubuisi Uwaezuoke Christopher Eke Maria Udorah Chinedu Idoko Anthony Ikefuna Ifeoma Emodi
author_sort	Osita Ezenwosu
title	Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting
title_short	Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting
title_full	Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting
title_fullStr	Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting
title_full_unstemmed	Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting
title_sort	clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting
publisher	BMC
publishDate	2021
url	https://doaj.org/article/91dec0e3c0ae4749921196f3e992e468
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Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting

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