The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance

Jia Feng,1,2 Shiyin Lu,1,2 Biqian Ou,1,2 Qian Liu,1,2 Jiaxin Dai,1,2 Chunyan Ji,1,2 Haiqing Zhou,1,2 Hongke Huang,1,2 Yi Ma1,2 1Institute of Biomedicine, Department of Cellular Biology, Jinan University, Guangzhou, People’s Republic of China; 2National Engineering Research Center of Geneti...

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Autores principales:	Feng J, Lu S, Ou B, Liu Q, Dai J, Ji C, Zhou H, Huang H, Ma Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	jnk signaling pathway obesity insulin resistance type 2 diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/91e541cb280a47dbaba65aa69c19ee7f
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spelling	oai:doaj.org-article:91e541cb280a47dbaba65aa69c19ee7f2021-12-02T09:22:16ZThe Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance1178-7007https://doaj.org/article/91e541cb280a47dbaba65aa69c19ee7f2020-04-01T00:00:00Zhttps://www.dovepress.com/the-role-of-jnk-signaling-pathway-in-obesity-driven-insulin-resistance-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jia Feng,1,2 Shiyin Lu,1,2 Biqian Ou,1,2 Qian Liu,1,2 Jiaxin Dai,1,2 Chunyan Ji,1,2 Haiqing Zhou,1,2 Hongke Huang,1,2 Yi Ma1,2 1Institute of Biomedicine, Department of Cellular Biology, Jinan University, Guangzhou, People’s Republic of China; 2National Engineering Research Center of Genetic Medicine, Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, People’s Republic of ChinaCorrespondence: Yi MaInstitute of Biomedicine, Department of Cellular Biology, Jinan University, 601 Huangpu Ave West, Guangzhou, Guangdong 510632, People’s Republic of ChinaTel/Fax +86 20 8522 1983Email tmayi@jnu.edu.cnAbstract: Obesity is not only closely related to insulin resistance but is one of the main factors leading to the formation of Type 2 Diabetes (T2D) too. The c-Jun N-terminal kinase (JNK) family is a member of the mitogen-activated protein kinase (MAPK) superfamily. JNK is also one of the most investigated signal transducers in obesity and insulin resistance. JNK-centric JNK signaling pathway can be activated by growth factors, cytokines, stress responses, and other factors. Many researches have identified that the activated phosphorylation JNK negatively regulates insulin signaling pathway in insulin resistance which can be simultaneously regulated by multiple signaling pathways related to the JNK signaling pathway. In this review, we provide an overview of the composition of the JNK signaling pathway, its regulation of insulin signaling pathway, and the relationship between the JNK signaling pathway and other pathways in insulin resistance.Keywords: JNK signaling pathway, obesity, insulin resistance, type 2 diabetesFeng JLu SOu BLiu QDai JJi CZhou HHuang HMa YDove Medical Pressarticlejnk signaling pathwayobesityinsulin resistancetype 2 diabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1399-1406 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	jnk signaling pathway obesity insulin resistance type 2 diabetes Specialties of internal medicine RC581-951
spellingShingle	jnk signaling pathway obesity insulin resistance type 2 diabetes Specialties of internal medicine RC581-951 Feng J Lu S Ou B Liu Q Dai J Ji C Zhou H Huang H Ma Y The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance
description	Jia Feng,1,2 Shiyin Lu,1,2 Biqian Ou,1,2 Qian Liu,1,2 Jiaxin Dai,1,2 Chunyan Ji,1,2 Haiqing Zhou,1,2 Hongke Huang,1,2 Yi Ma1,2 1Institute of Biomedicine, Department of Cellular Biology, Jinan University, Guangzhou, People’s Republic of China; 2National Engineering Research Center of Genetic Medicine, Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, People’s Republic of ChinaCorrespondence: Yi MaInstitute of Biomedicine, Department of Cellular Biology, Jinan University, 601 Huangpu Ave West, Guangzhou, Guangdong 510632, People’s Republic of ChinaTel/Fax +86 20 8522 1983Email tmayi@jnu.edu.cnAbstract: Obesity is not only closely related to insulin resistance but is one of the main factors leading to the formation of Type 2 Diabetes (T2D) too. The c-Jun N-terminal kinase (JNK) family is a member of the mitogen-activated protein kinase (MAPK) superfamily. JNK is also one of the most investigated signal transducers in obesity and insulin resistance. JNK-centric JNK signaling pathway can be activated by growth factors, cytokines, stress responses, and other factors. Many researches have identified that the activated phosphorylation JNK negatively regulates insulin signaling pathway in insulin resistance which can be simultaneously regulated by multiple signaling pathways related to the JNK signaling pathway. In this review, we provide an overview of the composition of the JNK signaling pathway, its regulation of insulin signaling pathway, and the relationship between the JNK signaling pathway and other pathways in insulin resistance.Keywords: JNK signaling pathway, obesity, insulin resistance, type 2 diabetes
format	article
author	Feng J Lu S Ou B Liu Q Dai J Ji C Zhou H Huang H Ma Y
author_facet	Feng J Lu S Ou B Liu Q Dai J Ji C Zhou H Huang H Ma Y
author_sort	Feng J
title	The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance
title_short	The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance
title_full	The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance
title_fullStr	The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance
title_full_unstemmed	The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance
title_sort	role of jnk signaling pathway in obesity-driven insulin resistance
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/91e541cb280a47dbaba65aa69c19ee7f
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The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance

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