New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents

Abstract In neuroscience, single-shank penetrating multi-electrode arrays are standard for sequentially sampling several cortical sites with high spatial and temporal resolution, with the disadvantage of neuronal damage. Non-penetrating surface grids used in electrocorticography (ECoG) permit simult...

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Autores principales:	W. S. Konerding, U. P. Froriep, A. Kral, P. Baumhoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91e6155c772c4fc79d0444d89e7447e7
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id	oai:doaj.org-article:91e6155c772c4fc79d0444d89e7447e7
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spelling	oai:doaj.org-article:91e6155c772c4fc79d0444d89e7447e72021-12-02T15:08:12ZNew thin-film surface electrode array enables brain mapping with high spatial acuity in rodents10.1038/s41598-018-22051-z2045-2322https://doaj.org/article/91e6155c772c4fc79d0444d89e7447e72018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22051-zhttps://doaj.org/toc/2045-2322Abstract In neuroscience, single-shank penetrating multi-electrode arrays are standard for sequentially sampling several cortical sites with high spatial and temporal resolution, with the disadvantage of neuronal damage. Non-penetrating surface grids used in electrocorticography (ECoG) permit simultaneous recording of multiple cortical sites, with limited spatial resolution, due to distance to neuronal tissue, large contact size and high impedances. Here we compared new thin-film parylene C ECoG grids, covering the guinea pig primary auditory cortex, with simultaneous recordings from penetrating electrode array (PEAs), inserted through openings in the grid material. ECoG grid local field potentials (LFP) showed higher response thresholds and amplitudes compared to PEAs. They enabled, however, fast and reliable tonotopic mapping of the auditory cortex (place-frequency slope: 0.7 mm/octave), with tuning widths similar to PEAs. The ECoG signal correlated best with supragranular layers, exponentially decreasing with cortical depth. The grids also enabled recording of multi-unit activity (MUA), yielding several advantages over LFP recordings, including sharper frequency tunings. ECoG first spike latency showed highest similarity to superficial PEA contacts and MUA traces maximally correlated with PEA recordings from the granular layer. These results confirm high quality of the ECoG grid recordings and the possibility to collect LFP and MUA simultaneously.W. S. KonerdingU. P. FroriepA. KralP. BaumhoffNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q W. S. Konerding U. P. Froriep A. Kral P. Baumhoff New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents
description	Abstract In neuroscience, single-shank penetrating multi-electrode arrays are standard for sequentially sampling several cortical sites with high spatial and temporal resolution, with the disadvantage of neuronal damage. Non-penetrating surface grids used in electrocorticography (ECoG) permit simultaneous recording of multiple cortical sites, with limited spatial resolution, due to distance to neuronal tissue, large contact size and high impedances. Here we compared new thin-film parylene C ECoG grids, covering the guinea pig primary auditory cortex, with simultaneous recordings from penetrating electrode array (PEAs), inserted through openings in the grid material. ECoG grid local field potentials (LFP) showed higher response thresholds and amplitudes compared to PEAs. They enabled, however, fast and reliable tonotopic mapping of the auditory cortex (place-frequency slope: 0.7 mm/octave), with tuning widths similar to PEAs. The ECoG signal correlated best with supragranular layers, exponentially decreasing with cortical depth. The grids also enabled recording of multi-unit activity (MUA), yielding several advantages over LFP recordings, including sharper frequency tunings. ECoG first spike latency showed highest similarity to superficial PEA contacts and MUA traces maximally correlated with PEA recordings from the granular layer. These results confirm high quality of the ECoG grid recordings and the possibility to collect LFP and MUA simultaneously.
format	article
author	W. S. Konerding U. P. Froriep A. Kral P. Baumhoff
author_facet	W. S. Konerding U. P. Froriep A. Kral P. Baumhoff
author_sort	W. S. Konerding
title	New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents
title_short	New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents
title_full	New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents
title_fullStr	New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents
title_full_unstemmed	New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents
title_sort	new thin-film surface electrode array enables brain mapping with high spatial acuity in rodents
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/91e6155c772c4fc79d0444d89e7447e7
work_keys_str_mv	AT wskonerding newthinfilmsurfaceelectrodearrayenablesbrainmappingwithhighspatialacuityinrodents AT upfroriep newthinfilmsurfaceelectrodearrayenablesbrainmappingwithhighspatialacuityinrodents AT akral newthinfilmsurfaceelectrodearrayenablesbrainmappingwithhighspatialacuityinrodents AT pbaumhoff newthinfilmsurfaceelectrodearrayenablesbrainmappingwithhighspatialacuityinrodents
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New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents

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