Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis

Osteoarthritis is a common joint disease that is a major public health problem. Here, the authors identify a role for the NUDT7 protein in pathogenesis of the disease, and report the potential for NUDT7 to be a target for future therapies.

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Auteurs principaux: Jinsoo Song, In-Jeoung Baek, Churl-Hong Chun, Eun-Jung Jin
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/91ec857969d7456dbd74a7a0a8bc0425
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Résumé:Osteoarthritis is a common joint disease that is a major public health problem. Here, the authors identify a role for the NUDT7 protein in pathogenesis of the disease, and report the potential for NUDT7 to be a target for future therapies.