Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis

Osteoarthritis is a common joint disease that is a major public health problem. Here, the authors identify a role for the NUDT7 protein in pathogenesis of the disease, and report the potential for NUDT7 to be a target for future therapies.

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Auteurs principaux:	Jinsoo Song, In-Jeoung Baek, Churl-Hong Chun, Eun-Jung Jin
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/91ec857969d7456dbd74a7a0a8bc0425
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id	oai:doaj.org-article:91ec857969d7456dbd74a7a0a8bc0425
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spelling	oai:doaj.org-article:91ec857969d7456dbd74a7a0a8bc04252021-12-02T16:49:31ZDysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis10.1038/s41467-018-05787-02041-1723https://doaj.org/article/91ec857969d7456dbd74a7a0a8bc04252018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05787-0https://doaj.org/toc/2041-1723Osteoarthritis is a common joint disease that is a major public health problem. Here, the authors identify a role for the NUDT7 protein in pathogenesis of the disease, and report the potential for NUDT7 to be a target for future therapies.Jinsoo SongIn-Jeoung BaekChurl-Hong ChunEun-Jung JinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinsoo Song In-Jeoung Baek Churl-Hong Chun Eun-Jung Jin Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
description	Osteoarthritis is a common joint disease that is a major public health problem. Here, the authors identify a role for the NUDT7 protein in pathogenesis of the disease, and report the potential for NUDT7 to be a target for future therapies.
format	article
author	Jinsoo Song In-Jeoung Baek Churl-Hong Chun Eun-Jung Jin
author_facet	Jinsoo Song In-Jeoung Baek Churl-Hong Chun Eun-Jung Jin
author_sort	Jinsoo Song
title	Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
title_short	Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
title_full	Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
title_fullStr	Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
title_full_unstemmed	Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
title_sort	dysregulation of the nudt7-pgam1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/91ec857969d7456dbd74a7a0a8bc0425
work_keys_str_mv	AT jinsoosong dysregulationofthenudt7pgam1axisisresponsibleforchondrocytedeathduringosteoarthritispathogenesis AT injeoungbaek dysregulationofthenudt7pgam1axisisresponsibleforchondrocytedeathduringosteoarthritispathogenesis AT churlhongchun dysregulationofthenudt7pgam1axisisresponsibleforchondrocytedeathduringosteoarthritispathogenesis AT eunjungjin dysregulationofthenudt7pgam1axisisresponsibleforchondrocytedeathduringosteoarthritispathogenesis
_version_	1718383291047870464

Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis

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