HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE

Permethrin, is a synthetic insecticide of appreciably low mammalian toxicity, it is especially useful for household purposes. This work aimed to study the gonadotoxic effect of this insecticide in Swiss mice, using two oral doses of 2000 and 3000 mg/kg b. w. for 30 days. The daily dose was 1.66 mg/...

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Autor principal:	Khawla Jassim Balash
Formato:	article
Lenguaje:	EN
Publicado:	University of Baghdad, College of Veterinary Medicine 2000
Materias:	SWISS MICE PERMETHRIN INSECTICIDE Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/91f0723e51b040cf81c5514066ce0b31
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spelling	oai:doaj.org-article:91f0723e51b040cf81c5514066ce0b312021-11-09T11:36:37ZHISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE10.30539/ijvm.v24i2.11791609-56932410-7409https://doaj.org/article/91f0723e51b040cf81c5514066ce0b312000-12-01T00:00:00Zhttps://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/1179https://doaj.org/toc/1609-5693https://doaj.org/toc/2410-7409 Permethrin, is a synthetic insecticide of appreciably low mammalian toxicity, it is especially useful for household purposes. This work aimed to study the gonadotoxic effect of this insecticide in Swiss mice, using two oral doses of 2000 and 3000 mg/kg b. w. for 30 days. The daily dose was 1.66 mg/kg and 2.5 mg/kg of active ingredient of permethrin for group \| and group \|\| respectively. The effect was determined by counting the percentage of damaged seminiferous tubules, their average diameter, and the spermatogenesis rate, also the changes in body weight and in testes-to-body weight ratio. Results showed that the insecticide caused significant reduction in body weight, increase in testes weight, as well as testes-to-body weight ratio, seminiferous tubules in treated animals were found to increase in diameter showing low degrees of damage. Nevertheless, spermatogenic activity was almost normal but in descending order, and Leydig cells remained unaffected. It was concluded that permethrin, has a slight gonadotoxic effect at the doses used which may not really affect the fertility of animals at the doses used. Khawla Jassim BalashUniversity of Baghdad, College of Veterinary MedicinearticleSWISS MICEPERMETHRININSECTICIDEVeterinary medicineSF600-1100ENThe Iraqi Journal of Veterinary Medicine, Vol 24, Iss 2 (2000)
institution	DOAJ
collection	DOAJ
language	EN
topic	SWISS MICE PERMETHRIN INSECTICIDE Veterinary medicine SF600-1100
spellingShingle	SWISS MICE PERMETHRIN INSECTICIDE Veterinary medicine SF600-1100 Khawla Jassim Balash HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE
description	Permethrin, is a synthetic insecticide of appreciably low mammalian toxicity, it is especially useful for household purposes. This work aimed to study the gonadotoxic effect of this insecticide in Swiss mice, using two oral doses of 2000 and 3000 mg/kg b. w. for 30 days. The daily dose was 1.66 mg/kg and 2.5 mg/kg of active ingredient of permethrin for group \| and group \|\| respectively. The effect was determined by counting the percentage of damaged seminiferous tubules, their average diameter, and the spermatogenesis rate, also the changes in body weight and in testes-to-body weight ratio. Results showed that the insecticide caused significant reduction in body weight, increase in testes weight, as well as testes-to-body weight ratio, seminiferous tubules in treated animals were found to increase in diameter showing low degrees of damage. Nevertheless, spermatogenic activity was almost normal but in descending order, and Leydig cells remained unaffected. It was concluded that permethrin, has a slight gonadotoxic effect at the doses used which may not really affect the fertility of animals at the doses used.
format	article
author	Khawla Jassim Balash
author_facet	Khawla Jassim Balash
author_sort	Khawla Jassim Balash
title	HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE
title_short	HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE
title_full	HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE
title_fullStr	HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE
title_full_unstemmed	HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE
title_sort	histological changes in the testi of pure inbred swiss mice induced by permethrin insecticide
publisher	University of Baghdad, College of Veterinary Medicine
publishDate	2000
url	https://doaj.org/article/91f0723e51b040cf81c5514066ce0b31
work_keys_str_mv	AT khawlajassimbalash histologicalchangesinthetestiofpureinbredswissmiceinducedbypermethrininsecticide
_version_	1718441129307799552

HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE

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