The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy

Abstract The effectivity of diffusion-weighted MRI methods in detecting the epileptogenic zone (EZ) was tested. Patients with refractory epilepsy (N=25) who subsequently underwent resective surgery were recruited. First, the extent of white matter (WM) asymmetry from mean kurtosis (MK) was calculate...

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Autores principales:	Michaela Bartoňová, Marek Bartoň, Pavel Říha, Lubomír Vojtíšek, Milan Brázdil, Ivan Rektor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91f576322dcb4a01b39c3ce02f4d16b7
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spelling	oai:doaj.org-article:91f576322dcb4a01b39c3ce02f4d16b72021-12-02T18:34:07ZThe benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy10.1038/s41598-021-92804-w2045-2322https://doaj.org/article/91f576322dcb4a01b39c3ce02f4d16b72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92804-whttps://doaj.org/toc/2045-2322Abstract The effectivity of diffusion-weighted MRI methods in detecting the epileptogenic zone (EZ) was tested. Patients with refractory epilepsy (N=25) who subsequently underwent resective surgery were recruited. First, the extent of white matter (WM) asymmetry from mean kurtosis (MK) was calculated in order to detect the lobe with the strongest impairment. Second, a newly developed metric was used, reflecting a selection of brain areas with concurrently increased mean Diffusivity, reduced fractional Anisotropy, and reduced mean Kurtosis (iDrArK). A two-step EZ detection was performed as (1) lobe-specific detection, (2) iDrArK voxel-wise detection (with a possible lobe-specific restriction if the result of the first step was significant in a given subject). The method results were compared with the surgery resection zones. From the whole cohort (N=25), the numbers of patients with significant results were: 10 patients in lobe detection and 9 patients in EZ detection. From these subsets of patients with significant results, the impaired lobe was successfully detected with 100% accuracy; the EZ was successfully detected with 89% accuracy. The detection of the EZ using iDrArK was substantially more successful when compared with solo diffusional parameters (or their pairwise combinations). For a subgroup with significant results from step one (N=10), iDrArK without lobe restriction achieved 37.5% accuracy; lobe-restricted iDrArK achieved 100% accuracy. The study shows the plausibility of MK for detecting widespread WM changes and the benefit of combining different diffusional voxel-wise parameters.Michaela BartoňováMarek BartoňPavel ŘíhaLubomír VojtíšekMilan BrázdilIvan RektorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michaela Bartoňová Marek Bartoň Pavel Říha Lubomír Vojtíšek Milan Brázdil Ivan Rektor The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy
description	Abstract The effectivity of diffusion-weighted MRI methods in detecting the epileptogenic zone (EZ) was tested. Patients with refractory epilepsy (N=25) who subsequently underwent resective surgery were recruited. First, the extent of white matter (WM) asymmetry from mean kurtosis (MK) was calculated in order to detect the lobe with the strongest impairment. Second, a newly developed metric was used, reflecting a selection of brain areas with concurrently increased mean Diffusivity, reduced fractional Anisotropy, and reduced mean Kurtosis (iDrArK). A two-step EZ detection was performed as (1) lobe-specific detection, (2) iDrArK voxel-wise detection (with a possible lobe-specific restriction if the result of the first step was significant in a given subject). The method results were compared with the surgery resection zones. From the whole cohort (N=25), the numbers of patients with significant results were: 10 patients in lobe detection and 9 patients in EZ detection. From these subsets of patients with significant results, the impaired lobe was successfully detected with 100% accuracy; the EZ was successfully detected with 89% accuracy. The detection of the EZ using iDrArK was substantially more successful when compared with solo diffusional parameters (or their pairwise combinations). For a subgroup with significant results from step one (N=10), iDrArK without lobe restriction achieved 37.5% accuracy; lobe-restricted iDrArK achieved 100% accuracy. The study shows the plausibility of MK for detecting widespread WM changes and the benefit of combining different diffusional voxel-wise parameters.
format	article
author	Michaela Bartoňová Marek Bartoň Pavel Říha Lubomír Vojtíšek Milan Brázdil Ivan Rektor
author_facet	Michaela Bartoňová Marek Bartoň Pavel Říha Lubomír Vojtíšek Milan Brázdil Ivan Rektor
author_sort	Michaela Bartoňová
title	The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy
title_short	The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy
title_full	The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy
title_fullStr	The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy
title_full_unstemmed	The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy
title_sort	benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal mr-negative epilepsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/91f576322dcb4a01b39c3ce02f4d16b7
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The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy

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