Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study

Abstract Chemokines play an important role in the pathophysiology of dermatomyositis (DM) with interstitial pneumonia (IP). However, the relation between chemokines and the disease activity or prognosis of DM-IP has not been elucidated. We evaluated the serum C-C motif chemokine ligand (CCL) 2, Th1...

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Autores principales:	Katsuhiro Oda, Takuya Kotani, Tohru Takeuchi, Takaaki Ishida, Takeshi Shoda, Kentaro Isoda, Shuzo Yoshida, Yasuichiro Nishimura, Shigeki Makino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91f79f93e1e549bca0d054fc103025d0
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spelling	oai:doaj.org-article:91f79f93e1e549bca0d054fc103025d02021-12-02T12:32:25ZChemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study10.1038/s41598-017-01685-52045-2322https://doaj.org/article/91f79f93e1e549bca0d054fc103025d02017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01685-5https://doaj.org/toc/2045-2322Abstract Chemokines play an important role in the pathophysiology of dermatomyositis (DM) with interstitial pneumonia (IP). However, the relation between chemokines and the disease activity or prognosis of DM-IP has not been elucidated. We evaluated the serum C-C motif chemokine ligand (CCL) 2, Th1 chemokines (C-X-C motif chemokine ligand [CXCL] 9, CXCL10, CXCL11), and Th2 chemokine (CCL17) profiles of 30 patients, and examined the relation between these chemokines and the disease activity or prognosis of DM-IP. Initial serum CCL2 level was higher in the death group (P = 0.007). To determine the cut-off points effective as poor prognostic factors of DM-IP, ROC curve analysis was carried out on initial serum CCL2 level. The value that maximized the area under the ROC curve was 894 pg/mL (sensitivity: 100%, specificity: 70.8%). Serum CCL2, CXCL9, CXCL10, and CXCL11 levels were lower at 2 weeks after treatment initiation than before treatment. Serum CCL2, CXCL10, and CXCL11 levels at 2 weeks after treatment initiation were higher in the death group. Serum levels of chemokines such as CCL2, CXCL10, and CXCL11 may be possible biomarkers of disease activity and prognosis in DM-IP, and serum CCL2 level may be useful when deciding initial treatment.Katsuhiro OdaTakuya KotaniTohru TakeuchiTakaaki IshidaTakeshi ShodaKentaro IsodaShuzo YoshidaYasuichiro NishimuraShigeki MakinoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katsuhiro Oda Takuya Kotani Tohru Takeuchi Takaaki Ishida Takeshi Shoda Kentaro Isoda Shuzo Yoshida Yasuichiro Nishimura Shigeki Makino Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study
description	Abstract Chemokines play an important role in the pathophysiology of dermatomyositis (DM) with interstitial pneumonia (IP). However, the relation between chemokines and the disease activity or prognosis of DM-IP has not been elucidated. We evaluated the serum C-C motif chemokine ligand (CCL) 2, Th1 chemokines (C-X-C motif chemokine ligand [CXCL] 9, CXCL10, CXCL11), and Th2 chemokine (CCL17) profiles of 30 patients, and examined the relation between these chemokines and the disease activity or prognosis of DM-IP. Initial serum CCL2 level was higher in the death group (P = 0.007). To determine the cut-off points effective as poor prognostic factors of DM-IP, ROC curve analysis was carried out on initial serum CCL2 level. The value that maximized the area under the ROC curve was 894 pg/mL (sensitivity: 100%, specificity: 70.8%). Serum CCL2, CXCL9, CXCL10, and CXCL11 levels were lower at 2 weeks after treatment initiation than before treatment. Serum CCL2, CXCL10, and CXCL11 levels at 2 weeks after treatment initiation were higher in the death group. Serum levels of chemokines such as CCL2, CXCL10, and CXCL11 may be possible biomarkers of disease activity and prognosis in DM-IP, and serum CCL2 level may be useful when deciding initial treatment.
format	article
author	Katsuhiro Oda Takuya Kotani Tohru Takeuchi Takaaki Ishida Takeshi Shoda Kentaro Isoda Shuzo Yoshida Yasuichiro Nishimura Shigeki Makino
author_facet	Katsuhiro Oda Takuya Kotani Tohru Takeuchi Takaaki Ishida Takeshi Shoda Kentaro Isoda Shuzo Yoshida Yasuichiro Nishimura Shigeki Makino
author_sort	Katsuhiro Oda
title	Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study
title_short	Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study
title_full	Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study
title_fullStr	Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study
title_full_unstemmed	Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study
title_sort	chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/91f79f93e1e549bca0d054fc103025d0
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_version_	1718394107616821248

Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study

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