Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals

Abstract This study examined associations of thyroid hormone levels and insulin resistance (IR) in non-diabetic individuals. Using a cross-sectional design, 2007–2008 data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. NHANES participants ≥20 years of age with comp...

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Autores principales:	Chih-Yuan Wang, Tse-Ya Yu, Shyang-Rong Shih, Kuo-Chin Huang, Tien-Chun Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91f91ceba60342d2b8a1f48874e591e3
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spelling	oai:doaj.org-article:91f91ceba60342d2b8a1f48874e591e32021-12-02T15:07:56ZLow total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals10.1038/s41598-018-29087-12045-2322https://doaj.org/article/91f91ceba60342d2b8a1f48874e591e32018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29087-1https://doaj.org/toc/2045-2322Abstract This study examined associations of thyroid hormone levels and insulin resistance (IR) in non-diabetic individuals. Using a cross-sectional design, 2007–2008 data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. NHANES participants ≥20 years of age with complete data of interest were included. The homeostatic model assessment (HOMA) was used to quantify IR, and treated as a continuous variable. Self-reported diabetes or a fasting glucose ≥7 mmol/L were used as criteria to exclude diabetic subjects. Race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, hemoglobin A1C (HbA1C), high-density lipoprotein, triglyceride, vitamin D and C-reactive protein were covariates significantly associated with HOMA-IR. A total of 1,560 non-diabetic subjects were included in the analysis. When adjusted for all factors significant in the univariate analysis (race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, HbA1C, high-density lipoprotein, triglyceride, vitamin D, and CRP) low total triiodothyronine (TT3) and low free T3 (FT3) were significantly associated with decreased HOMA-IR (adjusted coefficient = −0.486, 95% confidence interval [CI]: −0.936, −0.036; adjusted coefficient = −1.151, 95% CI: −1.952, −0.350, respectively). Insulin resistance is associated with low thyroid hormone levels in non-diabetic individuals.Chih-Yuan WangTse-Ya YuShyang-Rong ShihKuo-Chin HuangTien-Chun ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Yuan Wang Tse-Ya Yu Shyang-Rong Shih Kuo-Chin Huang Tien-Chun Chang Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals
description	Abstract This study examined associations of thyroid hormone levels and insulin resistance (IR) in non-diabetic individuals. Using a cross-sectional design, 2007–2008 data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. NHANES participants ≥20 years of age with complete data of interest were included. The homeostatic model assessment (HOMA) was used to quantify IR, and treated as a continuous variable. Self-reported diabetes or a fasting glucose ≥7 mmol/L were used as criteria to exclude diabetic subjects. Race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, hemoglobin A1C (HbA1C), high-density lipoprotein, triglyceride, vitamin D and C-reactive protein were covariates significantly associated with HOMA-IR. A total of 1,560 non-diabetic subjects were included in the analysis. When adjusted for all factors significant in the univariate analysis (race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, HbA1C, high-density lipoprotein, triglyceride, vitamin D, and CRP) low total triiodothyronine (TT3) and low free T3 (FT3) were significantly associated with decreased HOMA-IR (adjusted coefficient = −0.486, 95% confidence interval [CI]: −0.936, −0.036; adjusted coefficient = −1.151, 95% CI: −1.952, −0.350, respectively). Insulin resistance is associated with low thyroid hormone levels in non-diabetic individuals.
format	article
author	Chih-Yuan Wang Tse-Ya Yu Shyang-Rong Shih Kuo-Chin Huang Tien-Chun Chang
author_facet	Chih-Yuan Wang Tse-Ya Yu Shyang-Rong Shih Kuo-Chin Huang Tien-Chun Chang
author_sort	Chih-Yuan Wang
title	Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals
title_short	Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals
title_full	Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals
title_fullStr	Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals
title_full_unstemmed	Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals
title_sort	low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/91f91ceba60342d2b8a1f48874e591e3
work_keys_str_mv	AT chihyuanwang lowtotalandfreetriiodothyroninelevelsareassociatedwithinsulinresistanceinnondiabeticindividuals AT tseyayu lowtotalandfreetriiodothyroninelevelsareassociatedwithinsulinresistanceinnondiabeticindividuals AT shyangrongshih lowtotalandfreetriiodothyroninelevelsareassociatedwithinsulinresistanceinnondiabeticindividuals AT kuochinhuang lowtotalandfreetriiodothyroninelevelsareassociatedwithinsulinresistanceinnondiabeticindividuals AT tienchunchang lowtotalandfreetriiodothyroninelevelsareassociatedwithinsulinresistanceinnondiabeticindividuals
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Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals

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