Evolution of antibody titres against Epstein–Barr virus and human herpesvirus 6A/B and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients
Abstract Epstein–Barr virus (EBV), human herpesvirus 6A/B (HHV-6A/B) and multiple sclerosis (MS)-associated retrovirus (MSRV) have been described as possible MS triggers. We analysed antibody titres against EBV and HHV-6, and MSRV envelope (env) mRNA expression, in the serum of pregnant multiple scl...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/91f9cbaf754b4c4f9db24bbc17e4b983 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:91f9cbaf754b4c4f9db24bbc17e4b983 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:91f9cbaf754b4c4f9db24bbc17e4b9832021-12-02T18:27:49ZEvolution of antibody titres against Epstein–Barr virus and human herpesvirus 6A/B and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients10.1038/s41598-021-87941-12045-2322https://doaj.org/article/91f9cbaf754b4c4f9db24bbc17e4b9832021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87941-1https://doaj.org/toc/2045-2322Abstract Epstein–Barr virus (EBV), human herpesvirus 6A/B (HHV-6A/B) and multiple sclerosis (MS)-associated retrovirus (MSRV) have been described as possible MS triggers. We analysed antibody titres against EBV and HHV-6, and MSRV envelope (env) mRNA expression, in the serum of pregnant multiple sclerosis patients (P-MS) to study their possible link to the clinical activity of MS during pregnancy and postpartum and their possible role as relapse predictors. For that purpose, serum samples were collected from 71 pregnant women (50 pregnant MS and 21 pregnant healthy controls—P-HC) during pregnancy and postpartum. Relating to antibody titres, IgM antibody titres against HHV-6A/B were significantly higher in P-MS than in P-HC both in each pregnancy trimester and in the postpartum period. Moreover, IgM antibody titres against HHV-6A/B were higher in P-MS who suffered a relapse during the postpartum. Regarding MSRV env mRNA expression, the prevalence in the first trimester of pregnancy was significantly higher in P-MS who suffered relapses during pregnancy. Summing it up, high IgM antibody titres against HHV-6A/B and MSRV env mRNA expression during the first trimester of pregnancy could act as relapse predictors for the gestation/postpartum periods.Silvia Pérez-PérezJuan Pablo CuelloMarisa Martínez-GinésBeatriz Pardo-RodríguezJosé Manuel García-DomínguezMaría Inmaculada Domínguez-MozoAlberto Lozano-RosMaría Ángel García-MartínezYolanda HiguerasAriana Meldaña-RiveraHaydee Goicochea-BriceñoAmalia Tejeda-VelardeJose Ignacio Fernández-VelascoSilvia MedinaRafael ArroyoLuisa María VillarRoberto Álvarez-LafuenteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Silvia Pérez-Pérez Juan Pablo Cuello Marisa Martínez-Ginés Beatriz Pardo-Rodríguez José Manuel García-Domínguez María Inmaculada Domínguez-Mozo Alberto Lozano-Ros María Ángel García-Martínez Yolanda Higueras Ariana Meldaña-Rivera Haydee Goicochea-Briceño Amalia Tejeda-Velarde Jose Ignacio Fernández-Velasco Silvia Medina Rafael Arroyo Luisa María Villar Roberto Álvarez-Lafuente Evolution of antibody titres against Epstein–Barr virus and human herpesvirus 6A/B and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients |
| description |
Abstract Epstein–Barr virus (EBV), human herpesvirus 6A/B (HHV-6A/B) and multiple sclerosis (MS)-associated retrovirus (MSRV) have been described as possible MS triggers. We analysed antibody titres against EBV and HHV-6, and MSRV envelope (env) mRNA expression, in the serum of pregnant multiple sclerosis patients (P-MS) to study their possible link to the clinical activity of MS during pregnancy and postpartum and their possible role as relapse predictors. For that purpose, serum samples were collected from 71 pregnant women (50 pregnant MS and 21 pregnant healthy controls—P-HC) during pregnancy and postpartum. Relating to antibody titres, IgM antibody titres against HHV-6A/B were significantly higher in P-MS than in P-HC both in each pregnancy trimester and in the postpartum period. Moreover, IgM antibody titres against HHV-6A/B were higher in P-MS who suffered a relapse during the postpartum. Regarding MSRV env mRNA expression, the prevalence in the first trimester of pregnancy was significantly higher in P-MS who suffered relapses during pregnancy. Summing it up, high IgM antibody titres against HHV-6A/B and MSRV env mRNA expression during the first trimester of pregnancy could act as relapse predictors for the gestation/postpartum periods. |
| format |
article |
| author |
Silvia Pérez-Pérez Juan Pablo Cuello Marisa Martínez-Ginés Beatriz Pardo-Rodríguez José Manuel García-Domínguez María Inmaculada Domínguez-Mozo Alberto Lozano-Ros María Ángel García-Martínez Yolanda Higueras Ariana Meldaña-Rivera Haydee Goicochea-Briceño Amalia Tejeda-Velarde Jose Ignacio Fernández-Velasco Silvia Medina Rafael Arroyo Luisa María Villar Roberto Álvarez-Lafuente |
| author_facet |
Silvia Pérez-Pérez Juan Pablo Cuello Marisa Martínez-Ginés Beatriz Pardo-Rodríguez José Manuel García-Domínguez María Inmaculada Domínguez-Mozo Alberto Lozano-Ros María Ángel García-Martínez Yolanda Higueras Ariana Meldaña-Rivera Haydee Goicochea-Briceño Amalia Tejeda-Velarde Jose Ignacio Fernández-Velasco Silvia Medina Rafael Arroyo Luisa María Villar Roberto Álvarez-Lafuente |
| author_sort |
Silvia Pérez-Pérez |
| title |
Evolution of antibody titres against Epstein–Barr virus and human herpesvirus 6A/B and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients |
| title_short |
Evolution of antibody titres against Epstein–Barr virus and human herpesvirus 6A/B and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients |
| title_full |
Evolution of antibody titres against Epstein–Barr virus and human herpesvirus 6A/B and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients |
| title_fullStr |
Evolution of antibody titres against Epstein–Barr virus and human herpesvirus 6A/B and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients |
| title_full_unstemmed |
Evolution of antibody titres against Epstein–Barr virus and human herpesvirus 6A/B and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients |
| title_sort |
evolution of antibody titres against epstein–barr virus and human herpesvirus 6a/b and expression of multiple sclerosis-associated retrovirus in the serum of pregnant multiple sclerosis patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/91f9cbaf754b4c4f9db24bbc17e4b983 |
| work_keys_str_mv |
AT silviaperezperez evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT juanpablocuello evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT marisamartinezgines evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT beatrizpardorodriguez evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT josemanuelgarciadominguez evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT mariainmaculadadominguezmozo evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT albertolozanoros evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT mariaangelgarciamartinez evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT yolandahigueras evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT arianameldanarivera evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT haydeegoicocheabriceno evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT amaliatejedavelarde evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT joseignaciofernandezvelasco evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT silviamedina evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT rafaelarroyo evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT luisamariavillar evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients AT robertoalvarezlafuente evolutionofantibodytitresagainstepsteinbarrvirusandhumanherpesvirus6abandexpressionofmultiplesclerosisassociatedretrovirusintheserumofpregnantmultiplesclerosispatients |
| _version_ |
1718377992953004032 |