Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.

Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.

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Indoleamine 2,3-dioxygenase 1 (IDO-1) is an immunosuppressive enzyme expressed in the placenta, neoplastic cells, and macrophages to reject T cells by converting tryptophan into kynurenine. However, the role of IDO-1 in brain immunity, especially in the meninges, is unclear. We aim to elucidate the...

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Main Authors: Rong Ji, Lixiang Ma, Xinyu Chen, Renqiang Sun, Li Zhang, Hexige Saiyin, Wenshi Wei
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/91fac1cfee3f4f3494d1c4d2f1e68ca4
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Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells
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