Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds

Jozic et al observe deregulated cytoskeleton components and elevated levels of cortisol and caveolin-1 in chronic wounds. They also show that inducible-keratinocyte specific Cav1 knockout or drug-induced cholesterol disruption in diabetic mice leads to accelerated wound closure suggesting a therapeu...

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Autores principales:	Ivan Jozic, Beatriz Abdo Abujamra, Michael H. Elliott, Tongyu C. Wikramanayake, Jelena Marjanovic, Rivka C. Stone, Cheyanne R. Head, Irena Pastar, Robert S. Kirsner, Fotios M. Andreopoulos, Juan P. Musi, Marjana Tomic-Canic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9200647e814e4ff098f4b58d91e1577e
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spelling	oai:doaj.org-article:9200647e814e4ff098f4b58d91e1577e2021-12-02T17:40:01ZGlucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds10.1038/s42003-021-02298-52399-3642https://doaj.org/article/9200647e814e4ff098f4b58d91e1577e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02298-5https://doaj.org/toc/2399-3642Jozic et al observe deregulated cytoskeleton components and elevated levels of cortisol and caveolin-1 in chronic wounds. They also show that inducible-keratinocyte specific Cav1 knockout or drug-induced cholesterol disruption in diabetic mice leads to accelerated wound closure suggesting a therapeutic approach for diabetic foot ulcers.Ivan JozicBeatriz Abdo AbujamraMichael H. ElliottTongyu C. WikramanayakeJelena MarjanovicRivka C. StoneCheyanne R. HeadIrena PastarRobert S. KirsnerFotios M. AndreopoulosJuan P. MusiMarjana Tomic-CanicNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ivan Jozic Beatriz Abdo Abujamra Michael H. Elliott Tongyu C. Wikramanayake Jelena Marjanovic Rivka C. Stone Cheyanne R. Head Irena Pastar Robert S. Kirsner Fotios M. Andreopoulos Juan P. Musi Marjana Tomic-Canic Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
description	Jozic et al observe deregulated cytoskeleton components and elevated levels of cortisol and caveolin-1 in chronic wounds. They also show that inducible-keratinocyte specific Cav1 knockout or drug-induced cholesterol disruption in diabetic mice leads to accelerated wound closure suggesting a therapeutic approach for diabetic foot ulcers.
format	article
author	Ivan Jozic Beatriz Abdo Abujamra Michael H. Elliott Tongyu C. Wikramanayake Jelena Marjanovic Rivka C. Stone Cheyanne R. Head Irena Pastar Robert S. Kirsner Fotios M. Andreopoulos Juan P. Musi Marjana Tomic-Canic
author_facet	Ivan Jozic Beatriz Abdo Abujamra Michael H. Elliott Tongyu C. Wikramanayake Jelena Marjanovic Rivka C. Stone Cheyanne R. Head Irena Pastar Robert S. Kirsner Fotios M. Andreopoulos Juan P. Musi Marjana Tomic-Canic
author_sort	Ivan Jozic
title	Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
title_short	Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
title_full	Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
title_fullStr	Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
title_full_unstemmed	Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
title_sort	glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9200647e814e4ff098f4b58d91e1577e
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Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds

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