Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

Kolloli et al. examine whether aggregation contributes to enhanced pathogenicity of Mycobacterium tuberculosis in a rabbit model of pulmonary infection. They demonstrate that aggregation increases the ability of M. tuberculosis to grow robustly and promote inflammation and host cell death in the rab...

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Autores principales:	Afsal Kolloli, Ranjeet Kumar, Pooja Singh, Anshika Narang, Gilla Kaplan, Alex Sigal, Selvakumar Subbian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9200d11ffb0243f6a25ca20a4c43df58
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spelling	oai:doaj.org-article:9200d11ffb0243f6a25ca20a4c43df582021-11-07T12:19:37ZAggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology10.1038/s42003-021-02769-92399-3642https://doaj.org/article/9200d11ffb0243f6a25ca20a4c43df582021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02769-9https://doaj.org/toc/2399-3642Kolloli et al. examine whether aggregation contributes to enhanced pathogenicity of Mycobacterium tuberculosis in a rabbit model of pulmonary infection. They demonstrate that aggregation increases the ability of M. tuberculosis to grow robustly and promote inflammation and host cell death in the rabbit lungs, thus increasing disease burden.Afsal KolloliRanjeet KumarPooja SinghAnshika NarangGilla KaplanAlex SigalSelvakumar SubbianNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Afsal Kolloli Ranjeet Kumar Pooja Singh Anshika Narang Gilla Kaplan Alex Sigal Selvakumar Subbian Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology
description	Kolloli et al. examine whether aggregation contributes to enhanced pathogenicity of Mycobacterium tuberculosis in a rabbit model of pulmonary infection. They demonstrate that aggregation increases the ability of M. tuberculosis to grow robustly and promote inflammation and host cell death in the rabbit lungs, thus increasing disease burden.
format	article
author	Afsal Kolloli Ranjeet Kumar Pooja Singh Anshika Narang Gilla Kaplan Alex Sigal Selvakumar Subbian
author_facet	Afsal Kolloli Ranjeet Kumar Pooja Singh Anshika Narang Gilla Kaplan Alex Sigal Selvakumar Subbian
author_sort	Afsal Kolloli
title	Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology
title_short	Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology
title_full	Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology
title_fullStr	Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology
title_full_unstemmed	Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology
title_sort	aggregation state of mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9200d11ffb0243f6a25ca20a4c43df58
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Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

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