Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics
Abstract Intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is the standard treatment modality in various types of retinal diseases. However, endophthalmitis remains the most serious complication. Despite the lack of evidence that antibiotics prevent endophthalmitis, topi...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/9201ac3ac32147808a34465d07612582 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:9201ac3ac32147808a34465d07612582 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:9201ac3ac32147808a34465d076125822021-12-02T12:40:40ZIncidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics10.1038/s41598-020-79377-w2045-2322https://doaj.org/article/9201ac3ac32147808a34465d076125822020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79377-whttps://doaj.org/toc/2045-2322Abstract Intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is the standard treatment modality in various types of retinal diseases. However, endophthalmitis remains the most serious complication. Despite the lack of evidence that antibiotics prevent endophthalmitis, topical antibiotics are still used routinely in Japan. We conducted a retrospective multicenter study by analyzing records from patients who underwent IVI of anti-VEGF agents with or without antibiotic treatment. In the analysis of a total of 147,440 eyes, the incidence of endophthalmitis was 0.007%: 0.005% with no use of antibiotics, 0.009% with antibiotic pretreatment, 0.012% with posttreatment, and 0.005% with pre- and posttreatment. There was no statistically significant difference among the four groups (chi-square test, p = 0.57). Most facilities used masks, sterilized gloves, and drapes. Nine of the 10 eyes that developed endophthalmitis received topical antibiotics, and all infected eyes underwent IVI with aflibercept, not the prefilled syringe delivery system. In four patients who received multiple IVI, the detection of causative bacteria revealed resistance to used antibiotics. Data from this large population, treated with or without antibiotics, suggests that antibiotic prophylaxis does not reduce the rate of endophthalmitis after IVI.Masakazu MoriokaYoshihiro TakamuraKazuki NagaiShigeo YoshidaJunya MoriMasaru TakeuchiTomoko SawadaKumiko SoneHisashi FukuyamaSentaro KusuharaTsutomu YasukawaTomoya MurakamiHitoshi TabuchiDaisuke NagasatoTakao HiranoTetsuo UedaTatsuya JujoHirofumi SasajimaYoshinori MitamuraKunihiro IshikawaMasaru InataniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Masakazu Morioka Yoshihiro Takamura Kazuki Nagai Shigeo Yoshida Junya Mori Masaru Takeuchi Tomoko Sawada Kumiko Sone Hisashi Fukuyama Sentaro Kusuhara Tsutomu Yasukawa Tomoya Murakami Hitoshi Tabuchi Daisuke Nagasato Takao Hirano Tetsuo Ueda Tatsuya Jujo Hirofumi Sasajima Yoshinori Mitamura Kunihiro Ishikawa Masaru Inatani Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics |
| description |
Abstract Intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is the standard treatment modality in various types of retinal diseases. However, endophthalmitis remains the most serious complication. Despite the lack of evidence that antibiotics prevent endophthalmitis, topical antibiotics are still used routinely in Japan. We conducted a retrospective multicenter study by analyzing records from patients who underwent IVI of anti-VEGF agents with or without antibiotic treatment. In the analysis of a total of 147,440 eyes, the incidence of endophthalmitis was 0.007%: 0.005% with no use of antibiotics, 0.009% with antibiotic pretreatment, 0.012% with posttreatment, and 0.005% with pre- and posttreatment. There was no statistically significant difference among the four groups (chi-square test, p = 0.57). Most facilities used masks, sterilized gloves, and drapes. Nine of the 10 eyes that developed endophthalmitis received topical antibiotics, and all infected eyes underwent IVI with aflibercept, not the prefilled syringe delivery system. In four patients who received multiple IVI, the detection of causative bacteria revealed resistance to used antibiotics. Data from this large population, treated with or without antibiotics, suggests that antibiotic prophylaxis does not reduce the rate of endophthalmitis after IVI. |
| format |
article |
| author |
Masakazu Morioka Yoshihiro Takamura Kazuki Nagai Shigeo Yoshida Junya Mori Masaru Takeuchi Tomoko Sawada Kumiko Sone Hisashi Fukuyama Sentaro Kusuhara Tsutomu Yasukawa Tomoya Murakami Hitoshi Tabuchi Daisuke Nagasato Takao Hirano Tetsuo Ueda Tatsuya Jujo Hirofumi Sasajima Yoshinori Mitamura Kunihiro Ishikawa Masaru Inatani |
| author_facet |
Masakazu Morioka Yoshihiro Takamura Kazuki Nagai Shigeo Yoshida Junya Mori Masaru Takeuchi Tomoko Sawada Kumiko Sone Hisashi Fukuyama Sentaro Kusuhara Tsutomu Yasukawa Tomoya Murakami Hitoshi Tabuchi Daisuke Nagasato Takao Hirano Tetsuo Ueda Tatsuya Jujo Hirofumi Sasajima Yoshinori Mitamura Kunihiro Ishikawa Masaru Inatani |
| author_sort |
Masakazu Morioka |
| title |
Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics |
| title_short |
Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics |
| title_full |
Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics |
| title_fullStr |
Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics |
| title_full_unstemmed |
Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics |
| title_sort |
incidence of endophthalmitis after intravitreal injection of an anti-vegf agent with or without topical antibiotics |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/9201ac3ac32147808a34465d07612582 |
| work_keys_str_mv |
AT masakazumorioka incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT yoshihirotakamura incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT kazukinagai incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT shigeoyoshida incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT junyamori incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT masarutakeuchi incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT tomokosawada incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT kumikosone incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT hisashifukuyama incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT sentarokusuhara incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT tsutomuyasukawa incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT tomoyamurakami incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT hitoshitabuchi incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT daisukenagasato incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT takaohirano incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT tetsuoueda incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT tatsuyajujo incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT hirofumisasajima incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT yoshinorimitamura incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT kunihiroishikawa incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics AT masaruinatani incidenceofendophthalmitisafterintravitrealinjectionofanantivegfagentwithorwithouttopicalantibiotics |
| _version_ |
1718393752387584000 |