Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial

Abstract We aimed to determine the efficacy of multiple micronutrient supplementation on the biomarkers of iron, zinc, and vitamin A status across anthropometric status categories in Vietnamese school children. In this 22-week randomised controlled trial, 347 undernourished, normal weight, or overwe...

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Autores principales:	Ngan T. D. Hoang, Liliana Orellana, Rosalind S. Gibson, Tuyen D. Le, Anthony Worsley, Andrew J. Sinclair, Nghien T. T. Hoang, Ewa A. Szymlek-Gay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9201b0c882154b85865a4d15f8915e4c
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spelling	oai:doaj.org-article:9201b0c882154b85865a4d15f8915e4c2021-12-02T14:26:54ZMultiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial10.1038/s41598-021-83129-92045-2322https://doaj.org/article/9201b0c882154b85865a4d15f8915e4c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83129-9https://doaj.org/toc/2045-2322Abstract We aimed to determine the efficacy of multiple micronutrient supplementation on the biomarkers of iron, zinc, and vitamin A status across anthropometric status categories in Vietnamese school children. In this 22-week randomised controlled trial, 347 undernourished, normal weight, or overweight/obese children aged 6–9 years were allocated to receive every school day a multiple micronutrient supplement (10 mg iron, 10 mg zinc, 400 µg vitamin A) or a placebo. Haematological indices; circulating ferritin, zinc, and retinol (corrected for inflammation); and C-reactive protein were measured at baseline and 22 weeks. At week 22, linear mixed models showed that mean corpuscular volume increased by 0.3 fL, serum ferritin by 9.1 µg/L, plasma zinc by 0.9 µmol/L, and plasma retinol by 15%, and the prevalence of zinc deficiency decreased by 17.3% points in the intervention group compared to placebo. No intervention effects were found for other haematological indices, or the prevalence of anaemia. Multiple micronutrient supplementation for 22 weeks improved the biomarkers of zinc and vitamin A status and some biomarkers of iron status, and reduced the prevalence of zinc deficiency in Vietnamese school children. Trial registration: This trial was registered on 06/09/2016 at www.anzctr.org.au as ACTRN12616001245482.Ngan T. D. HoangLiliana OrellanaRosalind S. GibsonTuyen D. LeAnthony WorsleyAndrew J. SinclairNghien T. T. HoangEwa A. Szymlek-GayNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ngan T. D. Hoang Liliana Orellana Rosalind S. Gibson Tuyen D. Le Anthony Worsley Andrew J. Sinclair Nghien T. T. Hoang Ewa A. Szymlek-Gay Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial
description	Abstract We aimed to determine the efficacy of multiple micronutrient supplementation on the biomarkers of iron, zinc, and vitamin A status across anthropometric status categories in Vietnamese school children. In this 22-week randomised controlled trial, 347 undernourished, normal weight, or overweight/obese children aged 6–9 years were allocated to receive every school day a multiple micronutrient supplement (10 mg iron, 10 mg zinc, 400 µg vitamin A) or a placebo. Haematological indices; circulating ferritin, zinc, and retinol (corrected for inflammation); and C-reactive protein were measured at baseline and 22 weeks. At week 22, linear mixed models showed that mean corpuscular volume increased by 0.3 fL, serum ferritin by 9.1 µg/L, plasma zinc by 0.9 µmol/L, and plasma retinol by 15%, and the prevalence of zinc deficiency decreased by 17.3% points in the intervention group compared to placebo. No intervention effects were found for other haematological indices, or the prevalence of anaemia. Multiple micronutrient supplementation for 22 weeks improved the biomarkers of zinc and vitamin A status and some biomarkers of iron status, and reduced the prevalence of zinc deficiency in Vietnamese school children. Trial registration: This trial was registered on 06/09/2016 at www.anzctr.org.au as ACTRN12616001245482.
format	article
author	Ngan T. D. Hoang Liliana Orellana Rosalind S. Gibson Tuyen D. Le Anthony Worsley Andrew J. Sinclair Nghien T. T. Hoang Ewa A. Szymlek-Gay
author_facet	Ngan T. D. Hoang Liliana Orellana Rosalind S. Gibson Tuyen D. Le Anthony Worsley Andrew J. Sinclair Nghien T. T. Hoang Ewa A. Szymlek-Gay
author_sort	Ngan T. D. Hoang
title	Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial
title_short	Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial
title_full	Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial
title_fullStr	Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial
title_full_unstemmed	Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial
title_sort	multiple micronutrient supplementation improves micronutrient status in primary school children in hai phong city, vietnam: a randomised controlled trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9201b0c882154b85865a4d15f8915e4c
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Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial

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